5-Fluoroorotic acid monohydrate → 5-Fluorouracil

HRID 2052724Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2052724
O.C(O)(=O)C1NC(=O)NC(=O)C=1.O.[F:14][C:15]1[C:23](=[O:24])[NH:22][C:21](=[O:25])[NH:20][C:16]=1C(O)=O>>[F:14][C:15]1[C:23](=[O:24])[NH:22][C:21](=[O:25])[NH:20][CH:16]=1

Komponenten

3

Edukt 2

HCID 162127495-Fluoroorotic acid monohydrateHCID 162185041,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid monohydrate

Produkt 1

HCID 33855-Fluorouracil

Reaktionsbedingungen

Temperatur
260 °C

Versuchsvorschrift

In the reaction, the conversion of the orotic acid monohydrate was 100% and the yield of 5-fluoro-orotic acid monohydrate was 85.0%. The crystals were heated at 260° C. under a reduced pressure of lower than 1 mmHg to perform the decarboxylation to obtain 22.5 g of 5-fluorouracil.

Aufarbeitung

  1. customIn the reaction

Quellen und Nachweise

ORD-Eintrag
ord-efbca071b4d343cf9aff19e00611d2dd
Quelldatensatz
uspto-grants-1980_01
Patentnummer
US04186266

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