Trifluoroiodomethane

Warning

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

Warning

H280 (72.1%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

P203, P280, P318, P405, P410+P403, and P501 (click each P-code to see the statement)

Chemical: Methane, trifluoroiodo-

Status: Active Update: 04-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/24892

Trifluoroiodomethane: Does not have an individual approval but may be used under an appropriate group standard

Minimally decreased female mean body weights, changes in serum thyroid hormone levels, and no reproductive or developmental toxicity observed in inhalation study of rats at 2% vapor concentration (whole-body exposure); [DOD] Does not deplete the ozone and possesses very low potential for global warming; [Merck Index] An irritant; Risk of irreversible adverse health effects; [Alfa Aesar MSDS] See Tetrafluoromethane.

Press. Gas (Comp.) (72.1%)

Germ cell mutagenicity - category 2

Germ cell mutagenicity - Category 2

Muta. 2

CSL00089

Nitrosyl chloride + TRIFLUOROMETHYL IODIDE + Methyl nitrite

A steel lecture bottle filled with methyl nitrite exploded approximately 45 minutes after being filled. Although methyl nitrite is known to be explosive when heated or exposed to flame, these conditions were not encountered during the synthesis or storage. The cylinder had originally been used to ship iodotrifluoromethane from the gas vendor, and had most recently been used to store nitrosyl chloride.

Explosive,Flammable,Toxic

Lessons Learned and recommendations:1. Never refill gas cylinders with highly reactive or corrosive compounds, including the original compound contained in the cylinder 2. Limit the amound of highly reactive, toxic, or flammable chemicals to the quantity necessary for planned experiments, or that will be used within a few months.

User-Reported

1500 [ppm]

17000 [ppm]

99000 [ppm]

The NOAEL of 7000 ppm from the reproductive/developmental inhalation study was used as the point of departure (POD) for workplace environmental exposure level (WEEL) value development. After the POD was adjusted to account for interindividual variability, duration of exposure, and database limitations, the resulting 8-hour time-weighted average WEEL value of 500 ppm is expected to provide a significant margin of safety against any potential adverse health effects in workers exposed to CF3I. A 15-minute short-term exposure limit of 1500 ppm was also established to protect workers from potential cardiac effects produced by acute, high-dose inhalation of CF3I.

CF3I has low acute inhalation toxicity. The no-observed adverse effect level (NOAEL) of CF3I for cardiac sensitization in dogs was 2000 ppm. In four-week inhalation exposures, the NOAEL for rats was 10,000 ppm, and the NOAEL for mice was 10,000 ppm. In a rat subchronic inhalation study, the lowest observed adverse effect level (LOAEL) was 20,000 ppm for thyroid-related effects; the NOAEL (for non-thyroid-related effects) was 20,000 ppm. In a rat reproductive/developmental inhalation toxicity study, 20,000 ppm CF3I produced minimal general toxicity and no indication of reproductive or developmental toxicity. The LOAEL for parental toxicity (based on thyroid hormone effects) was 2000 ppm, and ,excluding thyroid effects, the parental NOAEL was 7000 ppm CF3I. The thyroid effects in rats were considered of less relevance to human risk assessment than the other systemic effects because of known species-specific differences in sensitivity to thyroid hormone perturbations. CF3I had mixed results in various in vitro and in vivo genotoxicity assays. No chronic toxicity or carcinogenicity studies available.

Used as a trifluoromethylating agent, etchant gas, and alternative to chlorofluorocarbons (fire extinguishers and refrigeration); [Merck Index]

Trifluoroiodomethane (CF3I) is used primarily as a fire suppressant.