Cefotiam Hexetil Hydrochloride
Grundinformationen
- CAS
95789-30-3- Standard-SMILES
CC(OC(=O)OC1CCCCC1)OC(=O)C1=C(CSc2nnnn2CCN(C)C)CS[C@@H]2[C@H](NC(=O)Cc3csc(N)n3)C(=O)N12.Cl.Cl- InChIKey
FFSANQNELHESQJ-LWBICVDYSA-N- Summenformel
- C27H39Cl2N9O7S3
- Durchschnittliche Molmasse
- 768,8 g/mol
- Monoisotopische Masse
- 767,1511635
Überblick
Cefotiam hexetil dihydrochloride is the dihydrochloride salt of cefotiam 1-(cyclohexyloxycarbonyloxy)ethyl ester. It is used as a prodrug for cefotiam. It has a role as an antibacterial drug and a prodrug. It contains a cefotiam hexetil ester. It is functionally related to a cefotiam.
Namen und Bezeichner
- Bevorzugter Name
- Cefotiam Hexetil Hydrochloride
- IUPAC
- 1-cyclohexyloxycarbonyloxyethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;dihydrochloride
- Englischer Name
- SCE 2174
- Summenformel
- C27H38ClN9O7S3
- Molmasse
- 732.29
Namen und Synonyme
cefotiam hexetil hydrochloride95789-30-3cefotiam hexetil dihydrochlorideCefotiam hexetil HClCTM-HE3N1X7E8CLEcefotiam 1-(cyclohexyloxycarbonyloxy)ethyl ester dihydrochlorideCHEBI:31373DTXSID90241980Pansporin-TRefChem:124241DTXCID20164471
Weitere Namen anzeigen
SCE 2174Cefotiam ImpSCE 2174 USP/EP/BPCefotiam Impurity 15CTM-HE hydrochlorideCefotiam Hexetil 2HClSCE-2174 hydrochlorideCefotiam (mixture of Diastereomers)Cefotiam Impurity 11（Cefotiam Hexetil Hydrochloride）
(1RS)-1-Cyclohexyloxycarbonyloxyethyl (6R,7R)-7-(2-(2-aminothiazol-4-yl)acetylamino)-3-(1-(2-dimethylaminoethyl)-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate dihydrochloride5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-,1-(((cyclohexyloxy)carbonyl)oxy)ethyl Ester, Dihydrochloride, (6R-(6-alpha,7-beta))-1-(((cyclohexyloxy)carbonyl)oxy)ethyl (6R,7R)-7-(((2-amino-1,3-thiazol-4-yl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)sulfanyl)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate dihydrochloride;1-(((cyclohexyloxy)carbonyl)oxy)ethyl 7beta-(2-amino-1,3-thiazol-4-yl)acetamido-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)sulfanyl)methyl)-3,4-didehydrocepham-4-carboxylate dihydrochlorideCefotiam hexetil (hydrochloride)Cefotiam hexetil hydrochloride [JAN]1-cyclohexyloxycarbonyloxyethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;dihydrochloridePansporin TCefotiam Hexetil Hydrochloride (mixture of Diastereomers)
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 276 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 16
- Frei drehbare Bindungen
- 16
- Schwere Atome
- 48
- Formalladung
- 0
- Komplexität
- 1.160
Physikochemische Eigenschaften
- Schmelzpunkt
- 120 · 120-130°C
- storage temp.
- -20 °C · Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Yellow
- CAS Datenbank
- 95789 · 95789-30-3
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesSkin Sens. 1 (100%)
Sicherheitsdaten
- Toxizität
- LD50 in male, female mice, male, female rats (mg/kg): 1290, 1150, 1470, 1620 i.p.; >2000 s.c.; >5000 orally (Chiba)
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Anwendungen
BeschreibungCefotiam hexetil hydrochloride is an orally active, broad-spectrum cephalosporin useful in the treatment of bacterial infections. It is a prodrug hydrolyzed in the GI tract and absorbed as cefotiam. Cefotiam hexetil hydrochloride is reported to be especially potent against Streptococci strains.
VerwendenA semi-synthetic cephalosporin antibiotic. Antibacterial.
Anbieter59 Anbieter
北京华美互利生物化工010-56205725 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
苏州朗恩生物科技有限公司13921996628 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
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