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Cefotiam Hexetil Hydrochloride
SCE 2174 · Cefotiam Imp · SCE 2174 USP/EP/BP · Cefotiam Impurity 15 · CTM-HE hydrochloride · Cefotiam Hexetil 2HCl · SCE-2174 hydrochloride · cefotiam hexetil dihydrochloride
Identifikatoren & physikalische Daten
| CAS No. | 95789-30-3 |
|---|---|
| Summenformel | C27H39Cl2N9O7S3 |
| Durchschnittliche Molmasse | 768,8 g/mol |
| Monoisotopische Masse | 767,1511635 g/mol |
| SMILES | CC(OC(=O)OC1CCCCC1)OC(=O)C1=C(CSc2nnnn2CCN(C)C)CS[C@@H]2[C@H](NC(=O)Cc3csc(N)n3)C(=O)N12.Cl.Cl |
| InChIKey | FFSANQNELHESQJ-LWBICVDYSA-N |
| PubChem CID | 175647 |
| ChEMBL | CHEMBL6067681 |
| ChEBI | CHEBI:31373 |
| EC No. | 680-797-5 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 276 |
|---|---|
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 16 |
| Frei drehbare Bindungen | 16 |
| Schwere Atome | 48 |
| Formalladung | 0 |
| Komplexität | 1.160 |
| Schmelzpunkt | 120-130°C |
| Lagerbedingungen | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Löslichkeit | DMSO (Slightly), Methanol (Slightly) |
| Aggregatzustand | Solid |
| Farbe | White to Pale Yellow |
| CAS Datenbank | 95789-30-3 |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Skin Sens. 1 (100%) |
| Toxizität | LD50 in male, female mice, male, female rats (mg/kg): 1290, 1150, 1470, 1620 i.p.>2000 s.c.>5000 orally (Chiba) |
Anwendungen & Verwendung
Beschreibung
Cefotiam hexetil hydrochloride is an orally active, broad-spectrum cephalosporin useful in the treatment of bacterial infections. It is a prodrug hydrolyzed in the GI tract and absorbed as cefotiam. Cefotiam hexetil hydrochloride is reported to be especially potent against Streptococci strains.
Verwenden
A semi-synthetic cephalosporin antibiotic. Antibacterial.