Acetohexamid

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

DRUGS THAT MAY INCR RISK OF HYPOGLYCEMIA FROM SULFONYLUREAS INCL OTHER HYPOGLYCEMIC AGENTS, SULFONAMIDES, PROPRANOLOL, SALICYLATES, PHENYLBUTAZONE, PROBENECID, DICUMAROL, CHLORAMPHENICOL, MONOAMINE OXIDASE INHIBITORS, & ALCOHOL. /SULFONYLUREAS/

IN DIABETIC PT WITHOUT HEPATIC OR RENAL IMPAIRMENT, PLASMA HALF-LIFE...WAS NOT CHANGED BY CONCURRENT TREATMENT WITH PHENYLBUTAZONE, BUT THERE WAS CONSIDERABLE PROLONGATION OF HALF-LIFE OF ITS METABOLITE, HYDROXYHEXAMIDE, WHICH IS ALSO AN EFFECTIVE HYPOGLYCEMIC AGENT.

DAILY INGESTION ACETOHEXAMIDE (100 MG/KG) & PHENFORMIN (50 MG/KG) 7 DAYS WITH IP DIPHENYLHYDANTOIN RESTORED THIAMINE CONTENT.

CONCOMITANT ADMIN OF SALICYLIC ACID (20 MG/KG) WITH ACETOHEXAMIDE (30 MG/KG) IV TO DOGS INCR RENAL CLEARANCE OF METABOLITE HYDROXYHEXAMIDE.

For more Interactions (Complete) data for ACETOHEXAMIDE (19 total), please visit the HSDB record page.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=968-81-0]

HYPOGLYCEMIC REACTIONS, INCL COMA, MAY OCCUR. WHILE THEY ARE USUALLY NOT SEVERE, SEVERAL FATALITIES HAVE BEEN REPORTED.

Coma or altered mental status is generally the most important presenting sign in the majority (90%) of patients who have ingested excessive doses of the sulfonylureas ... /Sulfonylurea/

Acetohexamide

TR-050: Bioassay of Acetohexamide for Possible Carcinogenicity (CASRN 968-81-0) (1978 )

03/06/78

No Evidence

No Evidence

No Evidence

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

Acetohexamide

DILI Positive

oral

DOI:10.1016/j.drudis.2019.09.022

SULFONYLUREAS FOUND TERATOGENIC IN ANIMALS. /FROM TABLE, SULFONYLUREAS/

BIOASSAY CONDUCTED BY ADMINISTERING TEST CHEMICAL IN FEED TO FISCHER 344 RATS & B6C3F1 MICE FOR 103 WK. APPARENTLY ACETOHEXAMIDE WAS NOT CARCINOGENIC FOR EITHER SPECIES.

ACETOHEXAMIDE STIMULATED ENZYMES IN LIVER HOMOGENATES OF NORMAL & ALLOXAN-DIABETIC RATS. APPARENTLY DRUG INTERFERES WITH HEPATIC PROTEIN BIOSYNTHESIS & GLUCONEOGENESIS. ORAL.

... Groups of 35 male and female Fischer 344 rats were fed diets containing 10,000 or 20,000 ppm, acetoheximide for 103 wk. Matched controls consisted of 15 untreated rats of each sex. All surviving rats were killed at 105 to 107 wk. Groups of 35 male and female mice were fed diets containing a time-weighted avg of 6,359 or 12,718 ppm acetoheximide for 103 wk. Matched controls consisted of 15 untreated mice of each sex. All surviving animals were killed between 105 and 108 wk. Under the conditions of this study, acetohexamide was not carcinogenic in either Fischer 344 rats or B6C3F1 mice.

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

Therap cat: Antidiabetic

An orally effective hypoglycemic compound.

MEDICATION

...IS AVAILABLE IN 250- & 500-MG TABLETS.

...doses for Acetohexamide are 250 and 1500 mg.