HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Noradenalone hydrochloride
Noradrenalone Hydrochloride · 2-amino-1-(3,4-dihydroxyphenyl)ethan-1-one hydrochloride · Noradrenalone HCl · NORADRENALINE IMPURITY B · Norepinephrine Impurity 1 · Carbazochrome Impurity 23 · NORADRENALONE HYDROCHLORIDYL · Noradrenaline EP Impurity B HCl
Identifikatoren & physikalische Daten
| CAS No. | 5090-29-9 |
|---|---|
| Summenformel | C8H10ClNO3 |
| Durchschnittliche Molmasse | 203,62 g/mol |
| Monoisotopische Masse | 203,03492086 g/mol |
| SMILES | Cl.NCC(=O)c1ccc(O)c(O)c1 |
| InChIKey | ILTXTELYZNIJHL-UHFFFAOYSA-N |
| PubChem CID | 199831 |
| DTXSID | DTXSID30198929 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 83,6 |
|---|---|
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 13 |
| Formalladung | 0 |
| Komplexität | 172 |
| Schmelzpunkt | 255 °C |
| Lagerbedingungen | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Löslichkeit | DMSO (Slightly, Heated), Water (Very Slightly, Heated) |
| Aggregatzustand | Solid |
| Farbe | Dark Yellow to Dark Brown |
| InChI | InChI=1S/C8H9NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,10-11H,4,9H2 |
| InChIKey | ILTXTELYZNIJHL-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=C(O)C(O)=C1)CN.[H]Cl |
Anwendungen & Verwendung
Verwenden
Noradrenalone Hydrochloride is an intermediate of Norepinephrine (N674500), an antagonist of dibutyryl cyclic AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release.
Herstellung & Synthese
synthetische
Preparation by demethylation of a-amino-3,4-dimethoxy-acetophenone on heating with 37% hydrochloric acid for 2.5 h at 160–165° under carbon dioxide (85%).