Amfenac

HCID 2136

Grundinformationen

CAS
51579-82-9
Standard-SMILES
Nc1c(CC(=O)O)cccc1C(=O)c1ccccc1
InChIKey
SOYCMDCMZDHQFP-UHFFFAOYSA-N
Summenformel
C15H13NO3
Durchschnittliche Molmasse
255,27 g/mol
Monoisotopische Masse
255,08954328

Überblick

Amfenac is an oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a cyclooxygenase 2 inhibitor and a cyclooxygenase 1 inhibitor. It is a member of benzophenones, an amino acid, an oxo monocarboxylic acid, a substituted aniline and a primary amino compound. It is a conjugate acid of an amfenac(1-).

Namen und Bezeichner

Bevorzugter Name
Amfenac
IUPAC
2-(2-amino-3-benzoylphenyl)acetic acid
Englischer Name
amfenac
Summenformel
C15H13NO3
Molmasse
255.27

Namen und Synonyme

Amfenac51579-82-9Amfenaco(2-Amino-3-benzoylphenyl)acetic acidAmfenacum(2-Amino-3-benzoylphenyl)essigsaeureNSC-309467CHEBI:7591528O5C1J38ADTXSID901995332-(2-amino-3-(benzoyl)phenyl)acetic acid2-[2-amino-3-(benzoyl)phenyl]acetic acid
Weitere Namen anzeigen
SOYCMDCMZDHQFP-UHFFFAOYSA-NNepafenac Impurity 5(Amfenac)2-Amino-3-benzoylbenzeneacetic acidBenzeneacetic acid, 2-amino-3-benzoyl-Amfenac D5Q: What is Amfenac D5 Q: What is the CAS Number of Amfenac D5 Q: What is the storage condition of Amfenac D5 Q: What are the applications of Amfenac D5
RefChem:111914DTXCID501220242-Amino-3-benzoylbenzeneacetic acid, monosodium salt, monohydrate2-(2-amino-3-benzoylphenyl)acetic acidAmfenac (INN)AMFENAC [INN]NSC 309467Amfenac sodium salt hydrate

Datenbank-Bezeichner

CAS
51579-82-9
PubChem CID
2136
DTXSID
DTXSID90199533
ChEMBL
CHEMBL25146
ChEBI
CHEBI:75915
UNII
28O5C1J38A
Nikkaji
J11.225I

Eigenschaften

Berechnete Struktureigenschaften

XLogP
2,6
Polarare Oberfläche (TPSA)
80,4 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
4
Schwere Atome
19

Physikochemische Eigenschaften

Schmelzpunkt
121 · 121-123° (dec)
Siedepunkt
398.5 °C · 398.5°C (rough estimate)
Dichte
1.1654 · 1.1654 (rough estimate)
Brechungsindex
1.55 · 1.5500 (estimate)

Sicherheit und Regulatorisches

Sicherheitsdaten

Toxizität
LD50 in mice, rats (mg/kg): 615, 311 orally (Sancilio)

Chemie und Industrie

Pharmakologische Informationen

Mechanism of ActionAmfenac mediates its anti-inflammatory effects by inhibiting cyclo-oxygenases.

Anwendungen

VerwendenAnti-inflammatory.

Vor- und nachgelagerte Produkte

Anbieter13 Anbieter

深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
赛纳斯特化学(欢迎点击联系)021-60343070
常州翔龙医药科技有限公司18915873328 18915873328 · [email protected]
深圳振强药物研发有限公司+86-0755-66853366 +86-13670046396 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
Ergänzende Hinweise · 1 Eintrag

DefinitionChEBI: An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used fo the treatment of pain and inflammation following cataract surgery.

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