2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)

HCID 22230CAS 5949-29-1
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Grundinformationen

Standard-SMILES
O.O=C(O)CC(O)(CC(=O)O)C(=O)O
InChIKey
YASYEJJMZJALEJ-UHFFFAOYSA-N
Summenformel
C6H8O7.H2O
Durchschnittliche Molmasse
210,14 g/mol
Monoisotopische Masse
210,03756728

Überblick

Citric acid monohydrate is an organic molecular entity.

Namen und Bezeichner

Bevorzugter Name
2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)
IUPAC
2-hydroxypropane-1,2,3-tricarboxylic acid;hydrate
Englischer Name
Citric acid monohydrate
Summenformel
C6H10O8
Molmasse
210.1388

Namen und Synonyme

Citric acid monohydrate5949-29-1Citric acid hydrateCITRIC ACID, MONOHYDRATE1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monohydratecitric acid;hydrate2968PHW8QPDTXSID70746681,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1)Acidum citricum monohydrateCitiric acidSoothe Chewable
Weitere Namen anzeigen
citricPROPANONEMETHYL KETONEDIMETHYL KETONECtric AcidMonohydrate citric acidFEMA 3326Citronensαure-hydratCitric acid monohydrat
Surface WipesStop HairAlphacide ActivatorPURILABGREEN FRESHNATURE CLEANRefChem:6528AQUACETIC-30

Datenbank-Bezeichner

CAS
5949-29-1
PubChem CID
22230
DTXSID
DTXSID7074668
ChEMBL
CHEMBL2107737
ChEBI
CHEBI:31404
UNII
2968PHW8QP
EC Number
611-842-9、691-328-9、904-113-4

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
133 Ų
H-Brücken-Donoren
5
H-Brücken-Akzeptoren
8
Frei drehbare Bindungen
5
Schwere Atome
14

Experimentelle und physikochemische Eigenschaften

Chemical ClassesOther Classes -> Organic Acids
LogP-1.72
Density1.5 g/cm³
SolubilitySolubility in water, g/100ml at 20 °C: 59.2
Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
Decomposition175 °C

Physikochemische Eigenschaften

Schmelzpunkt
135 °C · 135 °C
Siedepunkt
56 °C760 · 56 °C760 mm Hg(lit.)
Dichte
0.791 g/mL · 0.791 g/mL at 25 °C(lit.)
Dampfdichte
2 · 2 (vs air)
Dampfdruck
184 mm · 184 mm Hg ( 20 °C)
Brechungsindex
20 · n20/D 1.359(lit.)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 1.6% (18 of 1100) of reports.

Warning

H315 (14.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1100 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

Gefahrenhinweise

Regulatory Information · 3 Einträge

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1)

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Citric acid, monohydrate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monohydrate: Environment tier I assessment
Fire HazardsCombustible. Finely dispersed particles form explosive mixtures in air.
Hazards Summary · 1 Eintrag

A mild eye irritant; Causes cough in acute inhalation studies of guinea pigs; Causes ataxia and respiratory depression in oral lethal-dose studies of mice; [RTECS] Aerosol causes skin, eye, and respiratory tract irritation; [ICSC] An irritant; May cause allergic reactions in sensitive individuals; [Sigma-Aldrich MSDS] See Citric acid.

EPA Safer ChemicalChemical: Citric acid, monohydrate
Chemical DangersThe solution in water is a weak acid. Attacks copper, zinc, aluminium and their alloys.

Sicherheit und Schutzausrüstung

Fire FightingUse water spray, foam, powder, carbon dioxide.
First Aid Measures · 4 Einträge

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink.

Safe StorageSeparated from strong bases and oxidants.
Spillage Disposal · 1 Eintrag

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Eye PreventionWear safety spectacles.
Fire PreventionNO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.

Toxikologische Informationen

Exposure RoutesThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Signs and Symptoms · 4 Einträge

Cough. Sore throat.

Redness.

Redness. Pain.

Burning sensation.

Sicherheitsdaten

wgk
1
tsca
Yes
ridadr
UN 1090 3/PG 2
hs_code
29181400
RTECS-Nr.
AL3150000
risk_code
11-36-66-67-41-36/37/38-37/38

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 4 Einträge

CLEANING SOLUTION FOR HEMODIALYSIS MACHINES

Acidifying Activity [MoA]; Anti-coagulant [EPC]; Calculi Dissolution Agent [EPC]; Calcium Chelating Activity [MoA]; Decreased Coagulation Factor Activity [PE]

DESINFECTANT SOLUTION FOR HEMODIALYSIS MACHINE

Acidifying Activity [MoA]; Anti-coagulant [EPC]; Calcium Chelating Activity [MoA]; Decreased Coagulation Factor Activity [PE]; Calculi Dissolution Agent [EPC]

MeSH Pharmacological Classification · 2 Einträge

Agents that prevent BLOOD CLOTTING.

Substances that bind to and sequester CALCIUM ions.

Verwendung und Herstellung

Uses · 2 Einträge

Used as an anticoagulant in blood banks, acidulant (beverages, confectionery, cheese, effervescent salts, pharmaceutical syrups, elixirs, effervescent powders, and tablets), antioxidant, sequestering agent to remove trace metals, and mordant to brighten colors; Also used to make alkyd resins and in electroplating, special inks, and analytical chemistry; [Merck Index]

Electroplating [Category: Plate]

U.S. Production2023: 4,729 lb
Industry UsesDispersing agent
Household ProductsInformation on 20 consumer products that contain Citric acid monohydrate in the following categories is provided:
Use Classification · 2 Einträge

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

General Manufacturing InformationWholesale and Retail Trade
Anwendungen · 1 Eintrag

VerwendenCitric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains the stability of active ingredients and is used as a preservative. It is also used as an acidulant to control pH and acts as an anticoagulant by chelating calcium in the blood. Additionally, Citric Acid Monohydrate is used as an acidulating, food additive, and synergist in antioxidant mixtures.

Darstellung · 1 Eintrag

synthetischeCurrently, the industrial production process for citric acid monohydrate crystals involves several steps. First, the citric acid fermentation liquid is separated from the solid-liquid to obtain a citric acid clear liquid. Then, the clear liquid undergoes purification via the calcium salt method (hydrogen calcium method), acidolysis, and decolorization. This purified solution is then heated, concentrated, and crystallized to produce anhydrous citric acid. The mother liquor remaining from this process is then filtered by plate and frame and added to a crystallization cylinder to reach a supersaturated state through cooling and precipitating the crystal. Once the temperature reaches around 13 ℃, the mixture undergoes centrifugal separation, and the resulting wet crystal is then dried in a dryer. The separated mother liquor, after being filtered, decolorized, and concentrated, is added back to the crystallization cylinder to repeat the above steps a total of four to five times. Finally, the mother liquor is returned to the extraction workshop for re-purification via chromatographic separation.

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
山西锦洋药用辅料有限公司18234787927
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
西安清言生物科技有限责任公司15339027915

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