Penicillin G Potassium

HCID 23664709
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Grundinformationen

CAS
113-98-4
Standard-SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
InChIKey
IYNDLOXRXUOGIU-LQDWTQKMSA-M
Summenformel
C16H17KN2O4S
Durchschnittliche Molmasse
372,5 g/mol
Monoisotopische Masse
372,0546097

Überblick

Benzylpenicillin potassium is organic potassium salt of benzylpenicillin. It contains a benzylpenicillin(1-).

Namen und Bezeichner

Bevorzugter Name
Penicillin G Potassium
IUPAC
potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Englischer Name
Penicillin G potassium salt
Summenformel
C16H17KN2O4S
Molmasse
373.49

Namen und Synonyme

Penicillin G potassium113-98-4Benzylpenicillin potassiumPenicillin G potassium saltPotassium benzylpenicillinPotassium penicillin GPentidsBenzylpenicillin potassium saltPenicillin G KPotassium benzylpenicillinatePfizerpenbenzylpenicilline potassique
Weitere Namen anzeigen
Penicilline GPen-GPenicillin PotassiuMPenicillin G potassium First Crystalpotassium [2s-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
SugracillinCapicillinLiquapenScotcilTabilinPotassium salt of benzylpenicillinPfizerpen GPENICILLIN-2

Datenbank-Bezeichner

CAS
113-98-4
PubChem CID
23664709
DTXSID
DTXSID7045106
ChEMBL
CHEMBL1223
ChEBI
CHEBI:7963
UNII
VL775ZTH4C
EC Number
204-038-0

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
115 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
5
Frei drehbare Bindungen
4
Schwere Atome
24

Experimentelle und physikochemische Eigenschaften

Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Animal DrugsActive Ingredients (Penicillin G Potassium) -> FDA Greenbook
Collision Cross Section174.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Physikochemische Eigenschaften

Schmelzpunkt
214 · 214-217 C
Brechungsindex
294 ° · 294 ° (C=1, H2O)
storage temp.
-20 °C · Sealed in dry,Store in freezer, under -20°C
Löslichkeit
2 O: · H2O: 100 mg/mL
Aggregatzustand
powder
Farbe
Needles from butanol (aq)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H315 (16.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 80 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Status: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22421

Penicillin g potassium: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2.alpha.,5.alpha.,6.beta.)]-, monopotassium salt: Environment tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (16.2%)

Sicherheitsdaten

F
10-23
wgk
2
tsca
TSCA listed
hs_code
29411000
RTECS-Nr.
XH9700000
risk_code
42/43-34-11

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 4 Einträge

BUFFERED PENICILLIN G POTASSIUM

Penicillin-class Antibacterial [EPC]; Penicillins [CS]

PENICILLIN G POTASSIUM

Penicillins [CS]; Penicillin-class Antibacterial [EPC]

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.

Verwendung und Herstellung

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
General Manufacturing Information4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, potassium salt (1:1): ACTIVE
Anwendungen · 1 Eintrag

VerwendenPenicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.

Darstellung

synthetischePenicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.

Vor- und nachgelagerte Produkte

Anbieter100 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
清宁生物（江苏博泉生物科技有限公司）19352250998 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-).

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