Penicillin G Potassium
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Grundinformationen
- CAS
113-98-4- Standard-SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]- InChIKey
IYNDLOXRXUOGIU-LQDWTQKMSA-M- Summenformel
- C16H17KN2O4S
- Durchschnittliche Molmasse
- 372,5 g/mol
- Monoisotopische Masse
- 372,05460969
Überblick
Benzylpenicillin potassium is organic potassium salt of benzylpenicillin. It contains a benzylpenicillin(1-).
Namen und Bezeichner
- Bevorzugter Name
- Penicillin G Potassium
- IUPAC
- potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- Englischer Name
- Penicillin G potassium salt
- Summenformel
- C16H17KN2O4S
- Molmasse
- 373.49
Namen und Synonyme
Penicillin G potassium113-98-4Benzylpenicillin potassiumPenicillin G potassium saltPotassium benzylpenicillinPotassium penicillin GPentidsBenzylpenicillin potassium saltPenicillin G KPotassium benzylpenicillinatebenzylpenicilline potassiqueSugracillin
Weitere Namen anzeigen
Penicilline GPen-GPenicillin PotassiuMpfizerpenPenicillin G potassium First Crystalpotassium [2s-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
CapicillinLiquapenScotcilTabilinPotassium salt of benzylpenicillinPfizerpen GPENICILLIN-2Benzylpenicillinic acid potassium salt
Datenbank-Bezeichner
- CAS
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- Polarare Oberfläche (TPSA)
- 115 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 24
- Formalladung
- 0
- Komplexität
- 536
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Collision Cross Section174.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 214 · 214-217 C
- Brechungsindex
- 294 ° · 294 ° (C=1, H2O)
- storage temp.
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- 2 O: · H2O: 100 mg/mL
- Aggregatzustand
- powder
- Farbe
- Needles from butanol (aq)
- PH
- pH (10g/L, 25℃) : 5.0～7.5
- Wasserlöslichkeit
- Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform.
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H315 (16.2%): Causes skin irritation [Warning Skin corrosion/irritation]
P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 80 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
REACH registered substance: Potassium [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate (EC: 204-038-0)
Penicillin g potassium: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2.alpha.,5.alpha.,6.beta.)]-, monopotassium salt: Environment tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (16.2%)
Sicherheitsdaten
- F
- 10-23
- wgk
- 2
- tsca
- TSCA listed
- hs_code
- 29411000
- RTECS-Nr.
- XH9700000
- risk_code
- 42/43-34-11
- Toxizität
- LD50 oral in rabbit: 5848mg/kg
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
PENICILLIN G POTASSIUM
Penicillin-class Antibacterial [EPC]; Penicillins [CS]
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Verwendung und Herstellung
General Manufacturing Information4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, potassium salt (1:1): ACTIVE
Anwendungen
VerwendenPenicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.
Darstellung
synthetischePenicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.
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