Grundinformationen
- Standard-SMILES
CCNCC(=O)Nc1c(C)cccc1C- InChIKey
WRMRXPASUROZGT-UHFFFAOYSA-N- Summenformel
- C12H18N2O
- Durchschnittliche Molmasse
- 206,28 g/mol
- Monoisotopische Masse
- 206,1419132
Überblick
Monoethylglycinexylidide is amino acid amide formed from 2,6-dimethylaniline and N-ethylglycine components; an active metabolite of lidocaine, formed by oxidative deethylation. Used as an indicator of hepatic function. It has a role as a drug metabolite.
Namen und Bezeichner
- Bevorzugter Name
- Monoethylglycinexylidide
- IUPAC
- N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide
- Englischer Name
- Monoethylglycinexylidide
- Summenformel
- C12H18N2O
- Molmasse
- 206.28
Namen und Synonyme
Monoethylglycinexylidide7728-40-7NorlidocaineEthylglycylxylidideN-EthylglycinexylidideMEGX2-Ethylamino-2,6-acetoxylidine2-Ethylamino-2',6'-acetoxylidideAcetamide, N-(2,6-dimethylphenyl)-2-(ethylamino)-DTXSID60228006D8Q99HC770N-(2,6-dimethylphenyl)-N(2)-ethylglycinamide
Weitere Namen anzeigen
MGEXLidocaine-006Lidocaine Impurity 9Norlidocaine solution
CHEBI:222828RefChem:159573DTXCID40150497N-(2,6-Dimethylphenyl)-2-(ethylamino)acetamideLidocaine EP Impurity DL 86L-86L 86;Norlidocaine
Datenbank-Bezeichner
- CAS
7728-40-7- PubChem CID
- 24415
- DTXSID
DTXSID60228006- ChEMBL
CHEMBL1028- ChEBI
CHEBI:222828- UNII
- D8Q99HC770
- EC Number
- 694-788-9
- Nikkaji
- J55.345J
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 1,3
- Polarare Oberfläche (TPSA)
- 41,1 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 15
- Formalladung
- 0
- Komplexität
- 196
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals -> Metabolite of Lidocaine
Solubility25.2 [ug/mL] (The mean of the results at pH 7.4)
Physikochemische Eigenschaften
- Schmelzpunkt
- 242 · 242-245°C
- Siedepunkt
- 335.6 · 335.6±30.0℃ (760 Torr)
- Dichte
- 1.047 · 1.047±0.06 g/cm3 (20 ºC 760 Torr)
- Flammpunkt
- 127.8 · 127.8±24.7℃
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 2 O: · H2O: soluble10mg/mL, clear
- pka
- 8.04 · pKa 8.04(H2O,t =25±0.2,I=0.01(NaCl)) (Uncertain)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Wasserlöslichkeit
- 2 O: · H2O: 10mg/mL, clear
- Major Application
- pharmaceutical
- InChI
- 1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15)
- InChIKey
- WRMRXPASUROZGT-UHFFFAOYSA-N
- SMILES
- CC1=C(NC(CNCC)=O)C(C)=CC=C1
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 2811 6.1 / PGIII
- RTECS-Nr.
- AN7740000
- risk_code
- 22
- hazard_code
- Xn
- safety_code
- 45
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Acute Tox. 3 Oral
Chemie und Industrie
Pharmakologische Informationen
Metabolism/MetabolitesMonoethylglycinexylidide has known human metabolites that include 3-Hydroxymonoethyl glycinexylidide and Glycinexylidide.
Tissue LocationsKidney
Cellular LocationsCytoplasm
Metabolite PathwaysLidocaine (Antiarrhythmic) Action Pathway
Verwendung und Herstellung
Use ClassificationPharmaceuticals -> Transformation products
Anwendungen
VerwendenA metabolite of Lidocaine (L397800).
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Ergänzende Hinweise
DefinitionChEBI: Amino acid amide formed from 2,6-dimethylaniline and N-ethylglycine components; an active metabolite of lidocaine, formed by oxidative deethylation. Used as an indicator of hepatic function.
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