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Calciumhydrogenorthophosphat

Calcium hydrogen phosphate

HCID 24441
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Grundinformationen

CAS
7757-93-9
Standard-SMILES
O=P([O-])([O-])O.[Ca+2]
InChIKey
FUFJGUQYACFECW-UHFFFAOYSA-L
Summenformel
CaHO4P
Durchschnittliche Molmasse
136,06 g/mol
Monoisotopische Masse
135,9238364

Überblick

Calcium hydrogenphosphate is a calcium phosphate.

Namen und Bezeichner

Bevorzugter Name
Calcium hydrogen phosphate
IUPAC
calcium hydrogen phosphate
Lokaler Name
Calciumhydrogenorthophosphat
Englischer Name
Calcium phosphate dibasic
Summenformel
CaHO4P
Molmasse
136.06

Namen und Synonyme

7757-93-9CALCIUM HYDROGEN PHOSPHATECalcium phosphate dibasicDicalcium phosphatecalcium hydrogenphosphateDibasic calcium phosphateCalcium phosphate, dibasicBiofossecondary Calcium phosphateFujicalin SDicafos ANCalcium phosphate (1:1)
Weitere Namen anzeigen
MONOCALCIUM PHOSPHATEAnhydrous Dibasic Calcium PhosphateMonetiteDicalciumPhosphateAnhydrousCALCIUM ORTHOPHOSPHATEcalciumdibasicphosphate
Dicalcium orthophosphatePhosphoric acid, calcium salt (1:1)Anhydrous EmcompressIpifosc 20Calcium hydrogen orthophosphateMonocalcium acid phosphateCalcium acid phosphateCalcium monohydrogen phosphate

Datenbank-Bezeichner

CAS
7757-93-9
PubChem CID
24441
DTXSID
DTXSID20872529
ChEMBL

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
83,4 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
0
Schwere Atome
6
Formalladung
0
Komplexität
46,5

Experimentelle und physikochemische Eigenschaften

Chemical ClassesMetals -> Phosphates, Metallic Salts
Cosmetics · 2 Einträge

Cosmetic ingredients (Dicalcium Phosphate) -> CIR (Cosmetic Ingredient Review)

Abrasive; Opacifying; Bulking

OdorOdorless
TasteTasteless
Food Additives · 1 Eintrag

ANTICAKING AGENT OR FREE-FLOW AGENT, DOUGH STRENGTHENER, DRYING AGENT, EMULSIFIER OR EMULSIFIER SALT, HUMECTANT, LEAVENING AGENT, MASTICATORY SUBSTANCE, NUTRIENT SUPPLEMENT, PH CONTROL AGENT, STABILIZER OR THICKENER -> FDA Substance added to food

Density · 2 Einträge

2.89

Monoclinic crystals; density: 2.31 /Calcium hydrogen phosphate dihydrate, brushite/

Color/Form · 2 Einträge

Triclinic crystals

White crystalline powder

Solubility · 4 Einträge

Sparingly soluble in water. Insoluble in ethanol

Solubility: cold water 0.0316 g/100 cc @ 38 °C; hot water 0.075 g/100 cc @ 100 °C /Calcium hydrogen phosphate dihydrate/

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 3 Einträge

This chemical does not meet GHS hazard criteria for 97.2% (455 of 468) of all reports.

Not Classified

Aggregated GHS information provided per 468 reports by companies from 5 notifications to the ECHA C&L Inventory.

Gefahrenhinweise

Regulatory Information · 4 Einträge

Chemical: Phosphoric acid, calcium salt (1:1)

Phosphoric acid, calcium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphoric acid, calcium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Calcium hydrogenorthophosphate (EC: 231-826-1)

Calcium phosphate, dibasic: Non hazardous

Other Safety InformationIMAP assessments - Phosphoric acid, calcium salt (1:1): Human health tier I assessment
Fire PotentialNONFLAMMABLE.
Hazards SummaryA skin and eye irritant; [HSDB] An irritant; [MSDSonline] See Calcium.
FDA Requirements · 5 Einträge

Substances classified as stabilizers, when migrating from food-packaging material shall incl ... calcium hydrogen phosphate.

Calcium phosphate (mono-, di-, and tribasic) used as a multiple purpose GRAS food substance in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/

Calcium phosphate (mono-, di-, and tribasic) used as a nutrient in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/

Chemie und Industrie

Pharmakologische Informationen

Absorption, Distribution and Excretion... ITS ELEMENTS ARE SLOWLY ABSORBED FROM SMALL INTESTINE.

Verwendung und Herstellung

Uses · 6 Einträge

CIR ingredient: Dicalcium Phosphate

Used in powdered drink mixes (buffering agent), effervescent tablets, antacids, baking products (leavening agent), animal feeds, mineral supplements, dental products, medications (pelletizing aid and thickening agent), and fertilizers; Also used in the production of ceramics, plastics, and glass; [HSDB]

Glass Manufacturing [Category: Industry]

Ceramics making [Category: Hobbies]

Control acidity in powdered drink mixes, ingredient in effervescent tablets, as a plastics stabilizer, and in ceramics. Its single largest application is as a leavening agent in bread, cake mixes, and self-rising flour.

Chiefly in animal feeds; mineral supplement in cereals and other foods; manuf of glass; in dental products, fertilizers.

ImpuritiesDicalcium phosphate, phosphoric acid.
U.S. Production2023: 250,000,000 - <400,000,000 lb
Consumer UsesNot Known or Reasonably Ascertainable
Industry UsesSoil amendments (fertilizers)
Methods of Manufacturing · 2 Einträge

... From calcium chloride & disodium phosphate; from tricalcium phosphate & phosphoric acid; where it is intermediate in prepn of hydroxyapatite.

Interaction of fluorine-free phosphoric acid with milk of lime.

Formulations/Preparations · 3 Einträge

GRADES: United States Pharmacopeia; "Food Chemicals Codex"; Dentrifice grade; Feed grade, 18.5 or 21% phosphorus.

Zugehörige Reaktionen

28
Reaktionsaufzeichnung erstellen
Reaktionsgleichung von HRID 27676
HRID 27676als Eduktuspto-grants-1980_09
Reaktionsgleichung von HRID 716609
HRID 716609als Eduktuspto-grants-2015_11
Reaktionsgleichung von HRID 894499
HRID 894499als Eduktuspto-grants-1981_08
Reaktionsgleichung von HRID 971590
HRID 971590als Eduktuspto-grants-1979_07
Reaktionsgleichung von HRID 1027325
HRID 1027325als Eduktuspto-grants-2014_05
Reaktionsgleichung von HRID 1106224
HRID 1106224als Eduktuspto-grants-1982_01
Reaktionsgleichung von HRID 1109699
HRID 1109699als Eduktuspto-grants-1994_06
Reaktionsgleichung von HRID 1277500
HRID 1277500als Eduktuspto-grants-1981_07
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CHEMBL2107567
ChEBI
CHEBI:32596
UNII
L11K75P92J
EC Number
231-826-1
Nikkaji
J43.741G

Practically insol in water, alc

Sol in dil hydrochloric, nitric & acetic acids

Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Refractive IndexIndex of refraction = 1.5576, 1.5457, 1.5392 /Calcium hydrogen phosphate dihydrate/
Physical Description · 3 Einträge

Large Crystals; CBI; Dry Powder; Other Solid

White crystals or granules, granular powder or powder

Solid; Practically insoluble in water; [Merck Index] White powder; Insoluble in water; [MSDSonline]

Physikochemische Eigenschaften

Schmelzpunkt
370 °C · 370°C(decomposition)
Dichte
2.306 · 2.306(16℃)
storage temp.
2 · 2-8°C
Löslichkeit
Practically insoluble in water and in ethanol (96 per cent). It dissolves in dilute hydrochloric acid and in dilute nitric acid.
Aggregatzustand
gel (aged)
Farbe
White
PH
7 · 7 (10g/l, H2O, 20°C) suspension
Wasserlöslichkeit
Sparingly soluble in water, practically insoluble in cold water.
Merck
13 · 13,1697
Stabilität
Stable. Incompatible with strong oxidizing agents.
Major Application
pharmaceutical (small molecule)
Kosmetik-Inhaltsstoffe Funktionen
OPACIFYINGORAL CAREBULKINGABRASIVE
InChI
1S/Ca.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2
InChIKey
FUFJGUQYACFECW-UHFFFAOYSA-L
SMILES
[Ca++].OP([O-])([O-])=O
LogP
-2.148 · -2.148 (est)
CAS Datenbank
7757 · 7757-93-9(CAS DataBase Reference)
EPA chemische Informationen
Calcium hydrogen phosphate (7757-93-9)

Calcium phosphate (mono-, di-, and tribasic) used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. /Calcium phosphate (mono-, di-, and tribasic)/

Calcium phosphate (mono-, di-, andtribasic) used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. /Calcium phosphate (mono-, di-, and tribasic)/

Special Reports · 2 Einträge

Optimal Calcium Uptake. Current Bibliographies in Medicine 94-4. Public Services Division/National Library of Medicine. 775 citations from January, 1990-April, 1994. Available from: http://www.nlm.nih.gov/pubs/cbm/calcium.html

WHO; Diseases Caused by Phosphorus and Its Toxic Compounds; Early Detection of Occupational Diseases pg 53-62 (1986). Review of diseases and health related effects resulting from exposure to phosphorus or phosphorus cmpd.

FIFRA Requirements · 1 Eintrag

Residues of calcium phosphate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. /Calcium phosphate/

Hazard Classes and CategoriesNot Classified
Skin, Eye, and Respiratory IrritationsSkin and eye irritant.

Sicherheit und Schutzausrüstung

Disposal Methods · 1 Eintrag

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Preventive Measures · 1 Eintrag

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Allowable Tolerances · 1 Eintrag

Residues of calcium phosphate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. /Calcium phosphate/

Toxikologische Informationen

Toxicity Summary · 2 Einträge

The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Dicalcium Phosphate...

Safe for use in cosmetics, with qualifications

Natural Pollution SourcesOCCURS IN NATURE AS MINERAL MONETITE.
RAIS Toxicity Values · 4 Einträge

48.6

PPRTV Archive

8

PPRTV Current

Acceptable Daily Intakes · 1 Eintrag

FAO/WHO EXPERT COMMITTEE ON FOOD ADDITIVES...RECOMMENDED.../LEVELS/ FOR TOTAL DIETARY PHOSPHORUS...UNCONDITIONAL ACCEPTANCE LEVEL /OF LESS THAN 30 MG/KG BODY WT/ IS CONSIDERED SAFE IN ANY TYPE OF DIET...CONDITIONAL ACCEPTANCE LEVEL /OF 30-70 MG/KG BODY WT/ IS ACCEPTABLE ONLY WHEN DIETARY CALCIUM LEVEL IS HIGH /PHOSPHATES/

EPA Provisional Peer-Reviewed Toxicity Values · 5 Einträge

Dicalcium phosphate

8 mg/kg-day

PDF Document

Inadequate information to assess carcinogenic potential

2021

Regulatorische Informationen

FDA Requirements · 5 Einträge

Substances classified as stabilizers, when migrating from food-packaging material shall incl ... calcium hydrogen phosphate.

Calcium phosphate (mono-, di-, and tribasic) used as a multiple purpose GRAS food substance in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/

Calcium phosphate (mono-, di-, and tribasic) used as a nutrient in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/

Calcium phosphate (mono-, di-, and tribasic) used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. /Calcium phosphate (mono-, di-, and tribasic)/

Calcium phosphate (mono-, di-, andtribasic) used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. /Calcium phosphate (mono-, di-, and tribasic)/

FIFRA Requirements · 1 Eintrag

Residues of calcium phosphate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. /Calcium phosphate/

Sicherheitsdaten

wgk
3
tsca
TSCA listed
hs_code
2835 25 00
risk_code
36/37/38
Toxizität
LD50 orally in Rabbit: 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg
hazard_code
Xi
safety_code
26-36-24/25-22
Speicherklasse
11 - Combustible Solids
Giftige Stoffe Daten
7757-93-9(Hazardous Substances Data)

DOSAGE FORMS: CALCIUM PHOSPHATE & VITAMIN D (SQUIBB): EACH TABLET CONTAINS DIBASIC CALCIUM PHOSPHATE 228 MG, CALCIUM CARBONATE 45 MG, & VITAMIN D 330 IU.

Anhydrous and monohydrate salt

Household ProductsInformation on 13 consumer products that contain Dicalcium phosphate in the following categories is provided:
Use Classification · 5 Einträge

Food additives

Food Additives -> FLOUR_TREATMENT_AGENT; YEAST_FOOD -> JECFA Functional Classes

Food Additives -> FLOUR_TREATMENT_AGENT; YEAST_FOOD -> JECFA Functional Classes

Food Additives -> FLOUR_TREATMENT_AGENT; YEAST_FOOD -> JECFA Functional Classes

Cosmetics -> Abrasive; Opacifying; Bulking

General Manufacturing Information · 6 Einträge

Agriculture, Forestry, Fishing and Hunting

Phosphoric acid, calcium salt (1:1): ACTIVE

... CAN INACTIVATE METALLIC IONS, WHICH ARE CAPABLE OF INTERFERING WITH NECESSARY FOOD-PROCESSING REACTIONS ... /INACTIVATION IS/ EITHER BY PPTN & REMOVING THEM FROM INTERFERENCE WITH DESIRED FOOD-PROCESSING REACTIONS OR BY COMPLEXING & MAINTAINING THEM IN SOL, BOUND STATE. /PHOSPHATES/

Because calcium hydrogen phosphate is incongruently soluble, it is typically contaminated with various amounts (6-10%) of dicalcium phosphate and free phosphorus acid resulting from in-process disproportionation of the monocalcium salt.

Since phosphorus acid impurity may render the product hygroscopic and absorbed water and acid catalyzes further disproportionation, excess lime may be added to industrial monocalcium phosphate to ensure removal of residual free phosphoric acid. Therefore the product may contain dicalcium phosphate.

... The hygroscopic nature of anhydrous monocalcium phosphate limited its commercial applications. However, the addition of small amounts of potassium (+1), sodium (+1), and aluminum (+3) ions to the crystallization mother liquor ... results ... glassy coating protects the calcium phosphate from moisture and greatly improves its handling properties and performance in several applications ...

Anwendungen

VerwendenReplenisher (calcium); pharmaceutic aid (tablet base).

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

Calciumbis(dihydrogenorthophosphat)Phosphate rock powder2-(4-Dimethylaminophenylazo)benzoesaeureCalcium chloride solution 36-40%, (1box=27kgs)KalksteinCalciumoxidPHOS ROCK FERTILIZER IN BULKCalcium phosphate monobasiccalcium magnesium phosphate(CMP)NatriumchloridIndicatorCALCIUM SULFATE HEMIHYDRATEAcid Blue 93Harnstoffphosphoric acid by wet processSiliciumdioxidCalcium phosphate dibasic dihydrateSchwefelsureKaliumsulfat