Natriumthiosulfat

1.667

1.7 g/cm³

POWDER

COLORLESS MONOCLINIC CRYSTALS

PRACTICALLY INSOL IN ALCOHOL

50 G SOL IN 100 CC WATER; 231 G @ 100 °C

Solubility in water, g/100ml at 20 °C: 20.9

FDA approved drugs -> Active ingredient

EMA approved medicines: Human medicine

FDA approved drugs -> Active ingredient

Antidotes and other substances used in poisonings > Specific

DANGEROUS; WHEN HEATED TO DECOMP, THEY EMIT HIGHLY TOXIC FUMES OF /DISODIUM OXIDE AND SULFUR OXIDES/.

300 °C

Not Classified

Aggregated GHS information provided per 2963 reports by companies from 8 notifications to the ECHA C&L Inventory.

Chemical: Thiosulfuric acid (H2S2O3), disodium salt

Thiosulfuric acid (H2S2O3), sodium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Thiosulfuric acid (H2S2O3), sodium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 24-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14321

Sodium thiosulphate: Does not have an individual approval but may be used under an appropriate group standard

Potential combustible dust hazard; Decomposes slowly in water with potential generation of toxic and flammable hydrogen sulfide and corrosive hydrogen sulfite and sulfuric acid; Very soluble in water; Extremely low vapor pressure; May violently decomposes at 223 deg C; [CHEMINFO] ADI = 0-0.7 mg/kg; [JECFA] May be used in food up to 0.1%; [Hawley] See Potassium thiosulfate.

DRY TRITURATION WITH OXIDIZING AGENTS SUCH AS POTASSIUM CHLORATE, POTASSIUM PERMANGANATE, OR NITRATE MAY CAUSE EXPLOSION.

WHEN SODIUM NITRITE & THIOSULFATE MIXT WAS HEATED TO EVAPORATE TO DRYNESS, VIOLENT EXPLOSION OCCURRED.

Fresh air, rest.

Rinse and then wash skin with water and soap.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

Rinse mouth.

5.8 [mg/m3]

64 [mg/m3]

380 [mg/m3]

Drug Induced Liver Injury Rank (DILIrank 2.0)

Sodium thiosulfate

vNo-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

/ANTIFUNGAL ACTION OF SODIUM THIOSULFATE, USP,/...IS PROBABLY ATTRIBUTABLE TO SLOW RELEASE OF COLLOIDAL SULFUR.

IN CYANIDE POISONING, SODIUM NITRITE IS INJECTED IV...TO PRODUCE METHEMOGLOBIN WHICH COMBINES WITH...CYANIDE ION & RENDERS IT TEMPORARILY INACTIVE IN FORM OF CYANMETHEMOGLOBIN. SODIUM THIOSULFATE /USP/ IS THEN INJECTED IV TO FORM NONTOXIC THIOCYANATE.

THIOSULFATE SERVES AS SUBSTRATE FOR ENZYME RHODANESE, WHICH MEDIATES CONVERSION OF CYANIDE TO MUCH LESS TOXIC THIOCYANATE, WHICH IS EXCRETED IN URINE.

Agents counteracting or neutralizing the action of POISONS.

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.

Drugs used in the treatment of tuberculosis. They are divided into two main classes: first-line agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and second-line drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.

It is added in small quantities to ammonium thiosulfate, which is used as a photographic fixing salt. The hydrated salt is used as an anti-chlorine in bleaching, in wastewater purification, for reduction of dichromate in chromed leather production, and as a solvent for silver chloride in the chloride roasting of silver-containing minerals. [Ullmann] Used in paper bleaching, photography (fixer), silver extraction, dyeing textiles (mordant), and leather manufacturing; Also used as an antidote for cyanide poisoning and in vet medicine for bloat and ringworm; [Merck Index]

Pulp and Paper Processing [Category: Industry]

Applying metallic patinas [Category: Hobbies]

TO REMOVE CHLORINE FROM SOLN; AS "ANTICHLOR" IN BLEACHING OF PAPER PULP; FIXER IN PHOTOGRAPHY; MORDANT IN DYEING & PRINTING TEXTILES; REDUCER IN CHROME DYEING, MFR LEATHER; EXTRACTING OF SILVER FROM ORES; BLEACHING BONE, STRAW, IVORY; REAGENT IN ANALYTICAL CHEMISTRY; ANTIDOTE (CYANIDE POISONING)

SEQUESTRANT IN SALT

PHOTOGRAPHIC AGENT TO DISSOLVE SILVER HALIDES; AGENT IN CHROME LEATHER TANNING; ANTICHLOR IN BLEACHING CELLULOSE PRODUCTS; SOURCE OF SULFUR DIOXIDE IN BLEACHING VARIOUS PRODUCTS; PRESERVATIVE; CHEMICAL INTERMEDIATE

(1972) No Data

(1975) No Data

(1984) 6.54X10+9 g /Sodium Sulfite, Bisulfite, Metabisulfite, and Thiosulfate/

(1972) No Data

(1975) 3.44X10+8 GRAMS (INCL SULFITES)

(1984) 9.51X10+9 g /Sodium Sulfite/, Bisulfite, Metabisulfite, and Thiosulfate/

2023: 85,000,000 - <100,000,000 lb

(1972) 1.96X10+10 GRAMS

(1975) 1.7X10+10 GRAMS

90% FOR PHOTOGRAPHY; 5% FOR LEATHER TANNING; 5% FOR CHEMICALS AND MISC APPLICATIONS (1969)

Photographic, 25%; Anitchlor: Paper-25%, Water-20%, Chlor/Alkali-10%; Oil Well Drilling Muds, 10%; Tetramethyl Lead Manufacture, 5%; Other, 5% (1985)

BY-PRODUCT LIQUOR FROM SODIUM SULFIDE PRODUCTION IS REACTED WITH SULFUR DIOXIDE TO YIELD SODIUM THIOSULFATE; OR ORGANIC NITRO COMPOUNDS ARE BOILED WITH SODIUM POLYSULFIDE SOLUTION TO YIELD A LEACH LIQUOR OF SODIUM THIOSULFATE, WHICH IS THEN PURIFIED, CONCENTRATED AND CRYSTALLIZED

BY DISSOLVING SULFUR IN SODIUM SULFITE SOLN & THEN CRYSTALLIZING. IT IS ALSO PREPARED FROM WASTE LIQUORS OBTAINED IN PRODN OF SODIUM SULFIDE, LIQUORS CONTAINING SODIUM CARBONATE & SMALL AMT OF SODIUM SULFITE & SODIUM SULFATE IN ADDN TO SULFIDE.

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern

Food Additives -> ANTIOXIDANT; PRESERVATIVE; SEQUESTRANT -> JECFA Functional Classes

Food Additives -> ANTIOXIDANT; PRESERVATIVE; SEQUESTRANT -> JECFA Functional Classes

Cosmetics -> Reducing

All Other Basic Inorganic Chemical Manufacturing

Thiosulfuric acid (H2S2O3), sodium salt (1:2): ACTIVE

INCOMP: ACIDS DECOMP /IT/...WITH...PPTN /OF SULFUR & LIBERATION OF SO2/. IN ACID SOLN.../IT/ HAS REDUCING POWERS, & IS THEREFORE INCOMPATIBLE WITH OXIDIZING AGENTS. LEAD, SILVER & MERCUROUS SALTS PPT AS THIOSULFATES. SILVER HALIDES ARE MADE SOL BY.../IT/. BISMUTH SUBNITRATE IS PARTIALLY CONVERTED TO METALLIC BISMUTH.

SODIUM THIOSULFATE IS ONE OF INGREDIENTS WHICH MAY BE FOUND IN CHEMISTRY SETS. /FROM TABLE/