Zinnchlorid

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Give one or two glasses of water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

KEEP TIGHTLY CLOSED, IN A COOL PLACE. /DIHYDRATE/

CONTAINERS: BOTTLES; DRUMS.

If ... stannous chloride ... is spilled or leaked, the following steps should be taken: 1. Ventilate area of spill or leak. 2. Collect spilled or leaked material in the most convenient and safe manner for reclamation or for disposal. ... Liquid containing inorganic tin compounds should be absorbed in vermiculite, dry sand, earth, or a similar material.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

If employees' clothing may have become contaminated with solid stannous chloride ... employees should change into uncontaminated clothing before leaving the work premises. ... Non-impervious clothing which becomes wet with stannous chloride should be removed promptly and not reworn until the stannous chloride is removed from the clothing.

Clothing contaminated with stannous chloride /or/ stannic chloride ... should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of contaiminant from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the contaminant, the person performing the operation should be informed of contaminant's hazardous properties.

Skin that becomes contaminated with stannous chloride should be promptly washed to remove any stannous chloride. Employees who handle stannous chloride, stannic chloride ... should wash their hands thoroughly before eating, smoking, or using toilet facilities.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. All contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Oral (L308) ; inhalation (L308) ; dermal (L308)

Cough. Sore throat.

Redness. Pain.

Abdominal pain. Diarrhoea. Nausea. Vomiting.

Inorganic or organic tin compounds placed on the skin or in the eyes can produce skin and eye irritation. (L308)

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=7772-99-8]

In this study tin(II), as stannous chloride, is readily taken up by human white blood cells and can cause damage to DNA. Damage was detected in white blood cells after exposure to 10-50 uM tin(II) for 30 minutes at either 0 deg or 37 °C.

Organotin compounds examined in this study exhibited a relative order of potency for induction of in vitro hemolysis in human erythrocytes as follows: tri-n-butylitin > tri-n-propyltitn > tetra-n-butyltin > triphenyltin chloride > tri-n-ethyltin bromide > dibutyltin dichloride > stannous chloride > tri-n-methyltin chloride + butyltin chloride dihydroxide.

Stannous chloride

TR-231: Carcinogenesis Bioassay of Stannous Chloride (CASRN 7772-99-8) in F344/N Rats and B6C3F1/N Mice (Feed Study) (1982 )

06/23/81

Equivocal Evidence

No Evidence

No Evidence

THERE IS 1 REPORT ... OF PARALYSIS IN DOG AFTER LARGE DOSE (500 MG/KG) OF STANNOUS CHLORIDE IN MILK.

SEVERE GROWTH RETARDATION & OTHER SIGNS OF TOXICITY OCCURRED WITH STANNOUS CHLORIDE ... @ FEEDING LEVELS OF 0.3% /TO RATS/.

DOSE EFFECT OF INORGANIC TIN WAS EXAMINED IN MALE WISTAR RATS ORALLY ADMIN STANNOUS CHLORIDE (1, 3, 10, & 30 MG TIN/KG). EACH DOSE WAS ADMIN 6 TIMES @ 12 HR INTERVALS. DECREASES IN GASTRIC SECRETION, DUODENAL ALKALINE PHOSPHATASE & HEPATIC PHOSPHORYLASE ACTIVITIES, SERUM CALCIUM CONCN, FEMORAL CALCIUM CONTENT WERE FOUND. AT 3 MG/KG, THE CALCIUM CONTENT IN EPIPHYSIS OF THE FEMUR WAS SIGNIFICANTLY DECREASED BUT NOT AT 1 MG/KG. RESULTS SUGGEST THAT THE CRITICAL ORGAN IN INORGANIC TIN TOXICITY IS BONE.

WHEN ADMIN ORALLY TO RATS TWICE DAILY FOR 3 DAYS, STANNOUS CHLORIDE (3 MG TIN/100 G) INCR SERUM GLUCOSE CONCN & DECR SERUM INSULIN LEVEL AFTER A SINGLE ORAL GLUCOSE LOAD (0.2 G/100 %).

For more Non-Human Toxicity Excerpts (Complete) data for STANNOUS CHLORIDE (21 total), please visit the HSDB record page.

Stannous chloride is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Stannous chloride used as a chemical preservative in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.