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1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)

HCID 24670
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Grundinformationen

CAS
8004-13-5
Standard-SMILES
c1ccc(-c2ccccc2)cc1.c1ccc(Oc2ccccc2)cc1
InChIKey
MHCVCKDNQYMGEX-UHFFFAOYSA-N
Summenformel
C12H10O.C12H10
Durchschnittliche Molmasse
324,4 g/mol
Monoisotopische Masse
324,15141526

Überblick

Dowtherm appears as light to dark brown fragrant liquid. May float or sink in water. Freezing point is 54 °F. (USCG, 1999)

Namen und Bezeichner

Bevorzugter Name
1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)
IUPAC
1,1'-biphenyl;phenoxybenzene
Englischer Name
Phenyl ether-biphenyl eutectic
Summenformel
C24H20O
Molmasse
324.42

Namen und Synonyme

8004-13-5DiphylDOWTHERM ADowthermTherminol VPPhenyl ether, compd with biphenyl1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)RefChem:590410616-827-0PHENYL ETHER-BIPHENYL EUTECTICBiphenyl diphenyl ether eutecticDowtherm(R) A
Weitere Namen anzeigen
dowthermaDiphenyl ether-biphenyl eutecticBiphenyl-diphenyl etherbiphenyl/biphenylDowtherM A, 73.5%PhenylEther-Biphenyl
1,1'-biphenyl compound with oxydibenzene1,1'-biphenyl;phenoxybenzeneMFCD00148859Phenyl Ether-biphenyl Eutectic(w/w=7/3)DinilDinylHSDB 137Dowtherm-A

Datenbank-Bezeichner

CAS
8004-13-5
PubChem CID
24670
DTXSID
DTXSID9073387
EC Number
616-827-0

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
9,2 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
3
Schwere Atome
25
Formalladung
0
Komplexität
216

Experimentelle und physikochemische Eigenschaften

Chemical ClassesOther Classes -> Other Aromatic Compounds
Odor... Disagreeable aromatic odor.
Density · 3 Einträge

1.06 at 69.8 °F (USCG, 1999) - Denser than water; will sink

1.06 @ 25 °C/25 °C

(77 °F): 1.06

Color/FormColorless to straw-colored liquid or solid (below 54 degrees F) ... [Note: A mixture typically contains 75% phenyl ether & 25% biphenyl].
Solubility · 3 Einträge

Insoluble (NIOSH, 2024)

SOL IN ALC, ETHER, BENZENE; INSOL IN WATER

Insoluble

Flash Point · 4 Einträge

255 °F (USCG, 1999)

255 °F

255 °F OC.

239 °F

Boiling Point · 3 Einträge

494 °F at 760 mmHg (USCG, 1999)

257 °C

495 °F

Melting Point · 3 Einträge

54 °F (USCG, 1999)

12.2 °C

54 °F

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 4 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory InformationChemical: 1,1'-Biphenyl, mixture with 1,1'-oxybis[benzene]
Other Safety InformationIMAP assessments - 1,1'-Biphenyl, mixture with 1,1'-oxybis[benzene]: Human health tier I assessment
Fire HazardsSpecial Hazards of Combustion Products: Irritating gases generated when heated (USCG, 1999)
Fire PotentialMODERATE, WHEN EXPOSED TO HEAT OR FLAME... SPONTANEOUS HEATING: NO. /DIPHENYL OXIDE/
Health HazardsOdor of hot material may cause discomfort. Mildly irritating to eyes and skin. (USCG, 1999)
Hazards SummaryRats fed 0.5-1.0 g/kg 5 days a week for 132 doses show slightly increased liver weights. Irritating to the eyes, nose, and throat at concentrations of 3 to 4 ppm; [HSDB]
Reactive GroupEthers
Reactivity ProfileDOWTHERM is incompatible with the following: Strong oxidizers (NIOSH, 2024).

Chemie und Industrie

Verwendung und Herstellung

Uses · 3 Einträge

Used as a heat transfer medium at temperatures below 380 degrees C; [HSDB]

Dowtherm A is used as a heat transfer agent in the liquid or vapor phase at temperatures below 380 °C mainly in the manufacture of synthetic rubber, artificial fibers, plastics, and pigments.

Trademark for a group of liquid heat transfer media /Dowtherm/

U.S. Exports(1972) GREATER THAN 4.54X10+5 GRAMS
U.S. Imports · 2 Einträge

(1972) GREATER THAN 4.54X10+5 GRAMS

(1975) OVER 4.54X10+5 GRAMS

U.S. Production · 2 Einträge

(1972) GREATER THAN 4.54X10+5 GRAMS

(1975) OVER 4.54X10+5 GRAMS

Consumption Patterns100% AS A HEAT TRANSFER MEDIUM (1972)
Methods of ManufacturingIT IS EUTECTIC MIXT CONSISTING OF 73.5% PHENYL ETHER & 26.5% BIPHENYL BY WT.
General Manufacturing InformationIT IS USED WIDELY IN LIQ PHASE OR IN VAPOR PHASE AS A HEAT-TRANSFER AGENT @ TEMP BELOW 750 °F.

Anwendungen

VerwendenA fluid may be used in systems employing either liquid phase or vapor phase heating. Suitable applications include indirect heat transfer. Mainly in oil & gas, plastic processing, chemical processing, solar energy.

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Vapor Pressure · 4 Einträge

0.08 mmHg at 77 °F (NIOSH, 2024)

0.08 [mmHg]

0.08 MM HG @ 25 °C

(77 °F): 0.08 mmHg

Physical Description · 3 Einträge

Dowtherm appears as light to dark brown fragrant liquid. May float or sink in water. Freezing point is 54 °F. (USCG, 1999)

Colorless to straw-colored liquid or solid (below 54 degrees F) with a disagreeable, aromatic odor. [Note: A mixture typically contains 75% phenyl ether & 25% biphenyl.]; [NIOSH]

Colorless to straw-colored liquid or solid (below 54 °F) with a disagreeable, aromatic odor. [Note: A mixture typically contains 75% phenyl ether & 25% biphenyl.]

Autoignition Temperature1150 °F (USCG, 1999)
Other Experimental Properties · 2 Einträge

CONVERSION FACTORS @ 25 °C & 760 MM HG: 1 PPM= APPROX 6.79 MG/CU M; 1 MG/L= APPROX 147.3 PPM

log octanol/water partition coefficient = 4.55 /2-Biphenyl phenyl ether/

Physikochemische Eigenschaften

Schmelzpunkt
12 · 12-14 °C(lit.)
Siedepunkt
257 ℃ · 257℃
Dichte
1.06 · 1.06
Brechungsindex
20 · n20/D 1.590
Flammpunkt
123 °C · 123 °C
storage temp.
Store at room temperature
Aggregatzustand
Oil
Farbe
Colourless
Geruch (Odor)
Disagreeable aromatic odor
Wasserlöslichkeit
Insoluble in water.
InChI
InChI=1S/C12H10O.C12H10/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H;1-10H
InChIKey
MHCVCKDNQYMGEX-UHFFFAOYSA-N
SMILES
C1(C=CC=CC=1)C1=CC=CC=C1.C1(=CC=CC=C1)OC1=CC=CC=C1
EPA chemische Informationen
Phenyl ether-biphenyl mixture (8004-13-5)
Flammable LimitsClass IIIB Combustible Liquid: Fl.P. at or above 200 °F.
Air and Water ReactionsInsoluble in water.
NIOSH RecommendationsRecommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 ppm (7 mg/cu m).
Lower Explosive Limit (LEL)0.5 % At 500 °F: At 300 °F: 0.8%-3.3% (USCG, 1999)

Sicherheit und Schutzausrüstung

Fire FightingFire Extinguishing Agents: Water fog, foam, carbon dioxide, dry chemical (USCG, 1999)
First Aid · 2 Einträge

Excerpt from NIOSH Pocket Guide for Phenyl ether-biphenyl mixture (vapor):

(General first aid procedures)

Fire Fighting ProceduresWATER, FOAM, CARBON DIOXIDE, DRY CHEMICAL. /DIPHENYL OXIDE/
Disposal Methods · 1 Eintrag

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Preventive Measures · 3 Einträge

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Respirator RecommendationsNIOSH/OSHA
Permissible Exposure Limit (PEL) · 2 Einträge

1.0 [ppm]

TWA 1 ppm (7 mg/m3)

Recommended Exposure Limit (REL)TWA 1 ppm (7 mg/m3)
Personal Protective Equipment (PPE) · 6 Einträge

Excerpt from NIOSH Pocket Guide for Phenyl ether-biphenyl mixture (vapor):

Wear appropriate personal protective clothing to prevent skin contact.

Wear appropriate eye protection to prevent eye contact.

Recommendations for respirator selection. Max concn for use: 10 ppm. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. Eye protection needed. Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s) in combination with a high-efficiency particulate filter. Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having a high-efficiency particulate filter. Any powered, air-purifying respirator with organic vapor cartridge(s) in combination with a dust and mist filter. Eye protection needed. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.

Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.

Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having a high-efficiency particulate filter. Any appropriate escape-type, self-contained breathing apparatus.

Immediately Dangerous to Life or Health (IDLH) · 4 Einträge

10 ppm (NIOSH, 2024)

10.0 [ppm]

10 ppm

10 ppm

Toxikologische Informationen

Target OrgansEyes, skin, respiratory system
Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Exposure Routesinhalation, skin and/or eye contact
Signs and Symptomsirritation eyes, nose, skin; nausea
TSCA Test Submissions · 3 Einträge

Dowtherm (CAS # 8004-13-5) was evaluated for acute inhalation toxicity in 10 albino rats (sex and strain not indicated) by a single 8-hour exposure to vapor concentrations of 83.4 mg/l. The use of controls was not reported. All rats died within 24 hours of the beginning of exposure (5 rats died during exposure). No LD50 was determined and no clinical signs or necropsy results were reported.

Subchronic dermal toxicity was evaluated in a group of 4 New Zealand albino rabbits receiving 50 mg/kg/day applications of Dowtherm A to the clipped backs for a total of 20 consecutive applications; a control group containing 8 rabbits was also included in the study. Mortality was not observed. Clinical observations revealed mild to moderate erythema and edema. There were no treatment-related differences with respect to body weight changes, gross pathology, or testicular weights. No additional parameters were evaluated.

Dowtherm A (CAS # 8004-13-5) was evaluated for subchronic oral toxicity in a 30-day dietary feeding study in young and old rats. The test substance was administered at a dosage level of 175 mg/kg/day (5 females) and 600 mg/kg/day (5 females). No mortality or changes in the physical appearance or behavior occurred. Reduced body weights (day 29) and significant increases in brain to body weight ratios were observed in the 175 mg/kg/day. Reduced body weight gains were observed in the 600 mg/kg/day on days 3, 7, and 14. Dowtherm A appears not to affect liver or heart weight.

Human Toxicity Excerpts · 2 Einträge

When concn of 3 or 4 ppm in air are reached, there is irritation of the eyes, nose, and throat. In one instance a man received in the eyes a spray of fine droplets of Dowtherm under pressure. He felt no immediate discomfort, but within five minutes he began to feel stinging and burning of the eyes and also of the skin about his eyes; his discomfort was relieved immediately when the eyes and skin were washed with a bland oil. Slit lamp biomicroscopic examination shortly thereafter revealed no corneal injury.

SUMMARY TOXICITY STATEMENT /ACUTE/= MODERATE IRRITANT TO SKIN, EYES & MUCOUS MEMBRANE. MODERATE= MAY CAUSE REVERSIBLE OR IRREVERSIBLE CHANGES TO EXPOSED TISSUE, NOT PERMANENT INJURY OR DEATH; CAN CAUSE CONSIDERABLE DISCOMFORT.

Non-Human Toxicity Excerpts · 5 Einträge

SMALL GROUPS OF RATS WERE GIVEN REPEATED DOSES BY STOMACH TUBE...0.5-1.0 G/KG...5 DAYS/WK UNTIL 132 DOSES WERE ADMIN...RATS RECEIVING 0.5 G/KG DAILY SHOWED ONLY SLIGHT DEPRESSION OF GROWTH & SLIGHT WT INCR OF LIVER & KIDNEYS; THERE WERE NO HISTOPATHOLOGICAL CHANGES.

...RATS RECEIVING 1.0 G/KG DAILY /BY STOMACH TUBE/ SHOWED MODERATE DEPRESSION OF GROWTH, WITH SLIGHT TO MODERATE HISTOPATHOLOGICAL CHANGES IN KIDNEYS, & SLIGHT CHANGES IN LIVER & SPLEEN. KIDNEY SHOWED DEGENERATION OF TUBULES & HYALINE CAST FORMATION. ...LIVER ENLARGEMENT UP TO 188% NORMAL...

WHEN APPLIED DAILY TO EAR OF RABBIT, UNDILUTED DOWTHERM A PRODUCED BUT A SLIGHT IRRITATION MANIFESTED BY HYPEREMIA, EDEMA, EXFOLIATION, HAIR LOSS & ENLARGEMENT OF HAIR FOLLICLES...

EYE CONTACT WITH LIQ DOWTHERM A CAUSES PAIN & CONJUNCTIVAL IRRITATION BUT NO NECROSIS IN RABBIT.

For more Non-Human Toxicity Excerpts (Complete) data for DOWTHERM A (12 total), please visit the HSDB record page.

Probable Routes of Human ExposureUSE OF DOWTHERM INVOLVES SERIOUS DIFFICULTIES BECAUSE, EVEN THOUGH IT IS HEATED & KEPT IN CLOSED SYSTEM, SMALL QUANTITIES OF LIQ OR VAPOR MAY ESCAPE FROM JOINTS OR GASKETS, THUS POLLUTING ATMOSPHERE.

Sicherheitsdaten

OEB
B
OEL
TWA: 1 ppm (7 mg/m3)
wgk
2
IDLA
10 ppm
tsca
Yes
ridadr
UN 3082 9/PG 3
hs_code
29093090
risk_code
36/37/38-50/53
hazard_code
Xi,N
safety_code
26-60-61
hazard_class
9
packing_group
III
Giftige Stoffe Daten
8004-13-5(Hazardous Substances Data)