1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 178469560, Verbindung

HRID 48289

Reaktionsgleichung

Reaktionsgleichung von HRID 48289
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[NH:6][CH:7]=[C:8]([C:12]([O-:14])=O)[C:9]([O-:11])=[O:10].[CH:20]1C=CC(C2C=CC=CC=2)=C[CH:21]=1.C1C=CC(OC2C=CC=CC=2)=CC=1>>[OH:14][C:12]1[C:15]2[C:5](=[CH:4][C:3]([C:2]([F:1])([F:19])[F:18])=[CH:17][CH:16]=2)[N:6]=[CH:7][C:8]=1[C:9]([O:11][CH2:20][CH3:21])=[O:10]

Komponenten

3

Edukt 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 226483082-{[3-(Trifluoromethyl)anilino]methylene}malonate

Produkt 1

HCID 178469560HCID 178469560, Verbindung

Reaktionsbedingungen

Temperatur
240 °C

Versuchsvorschrift

Under a nitrogen atmosphere, a mixture of 2-{[3-(trifluoromethyl)anilino]methylene}malonate (80 g, 0.24 mol) and Dowtherm A was heated to 240° C. and then stirred for 3 hours. The reaction mixture was allowed to cool to ambient temperature and then stirred for 16 hours. The solids were isolated by filtration then washed with hexane to provide 47.5 g of ethyl 4-hydroxy-7-(trifluoromethyl)-3-quinolinecarboxylate as an off-white solid.

Aufarbeitung

  1. temperatureto cool to ambient temperature
  2. stirringstirred for 16 hours
  3. customThe solids were isolated by filtration
  4. washthen washed with hexane

Quellen und Nachweise

ORD-Eintrag
ord-f6a378c9d38b4ea78fc777c5acce1586
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703402B2

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