Kisspeptin-10
Grundinformationen
- CAS
374675-21-5- Standard-SMILES
CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O- InChIKey
RITKWYDZSSQNJI-INXYWQKQSA-N- Summenformel
- C63H83N17O14
- Durchschnittliche Molmasse
- 1.302,4 g/mol
- Monoisotopische Masse
- 1.301,63054039
Überblick
Kisspeptin-10 is under investigation in clinical trial NCT03771326 (KP-10 and Insulin Secretion in Men).
Namen und Bezeichner
- Bevorzugter Name
- Kisspeptin-10
- IUPAC
- (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]butanediamide
- Englischer Name
- Kisspeptin 10 (human)
- Summenformel
- C63H83N17O14
- Molmasse
- 1302.44
Namen und Synonyme
Kisspeptin-10374675-21-5Kisspeptin-10 (human)FS1N52VS3SHuman metastin 45-54RefChem:1088060Human kisspeptin 10FKisspeptin-10, humanKP-10Metastin 45-54UNII-FS1N52VS3SCHEMBL376756
Weitere Namen anzeigen
Kisspetin-10Kisspeptin-10 FragmentKisspeptin-10 acetateKiSS-1KISS-10YNWNSFGLRF - NH2KISS-1 (112-121)H-YNWNSFGLRF-NH2
NSC 741805Metastin (45-54)L-TYROSYL-L-ASPARAGINYL-L-TRYPTOPHYL-L-ASPARAGINYL-L-SERYL-L-PHENYLALANYLGLYCYL-L-LEUCYL-L-ARGINYL-L-PHENYLALANINAMIDEKisspeptin-13 (4-13) (human)KP10C63H83N17O14Kisspeptin 10Kisspeptin-10?
Datenbank-Bezeichner
- CAS
374675-21-5- PubChem CID
- 25240297
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -1,9
- Polarare Oberfläche (TPSA)
- 538 Ų
- H-Brücken-Donoren
- 18
- H-Brücken-Akzeptoren
- 16
- Frei drehbare Bindungen
- 38
- Schwere Atome
- 94
- Formalladung
- 0
- Komplexität
- 2.590
Physikochemische Eigenschaften
- Dichte
- 1.46 · 1.46±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- 15 mg/ml; · DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml
- Aggregatzustand
- A crystalline solid
- pka
- 9.96 · 9.96±0.15(Predicted)
- Farbe
- White to off-white
- Wasserlöslichkeit
- 1 mg/ml · Soluble in water at 1mg/ml
- InChIKey
- RITKWYDZSSQNJI-INXYWQKQSA-N
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungKisspeptin-10, also called Metastin (45-54), is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.
VerwendenKisspeptin 10 (human) is a powerful and specific activator for AXOR12 and hOT7T175 receptors. The Kisspeptin 10 (human) amide has been utilized in studies involving progesterone release from MA-10 cells and in experiments to induce gonadal differentiation in clownfish.
VerwendenKisspeptin-10 (human), a member of the kisspeptin family, is a neuropeptide that regulates gonadotropin secretion. It has anti-angiogenic effects, a concentration-dependent inhibition of HUVEC proliferation and migration, and is highly expressed in the placenta, which may help to regulate angiogenesis in this tissue. Kisspeptin-10 (human) is currently undergoing clinical studies with insulin secretion in men. It is also a potential drug target for the treatment of infertility.
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成都彼样生物科技有限公司18108052721 · [email protected]
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