Dichloroacetate anion

dichloroacetate ion · Dichloroacetate anion · ACETICACID,DICHLORO-,ION(1-)

Identifikatoren & physikalische Daten

CAS No.	13425-80-4
Summenformel	C2HCl2O2-
Durchschnittliche Molmasse	127,93 g/mol
Monoisotopische Masse	126,93590821 g/mol
SMILES	O=C([O-])C(Cl)Cl
InChIKey	JXTHNDFMNIQAHM-UHFFFAOYSA-M
PubChem CID	25975
ChEBI	CHEBI:28240
DTXSID	DTXSID40158610

Gesundheitliche Auswirkungen	Multiple independent studies demonstrate that DCA has the ability to alter normal carbohydrate metabolism. Dichloroacetic acid treatment results in a significant reduction in plasma levels of glucose, pyruvate, and lactate. Another consistent finding in DCA ingestion studies is a dose-related increase in liver size, generally accompanied (or caused) by an increase in glycogen deposition in the liver. There is an extensive and consistent data base demonstrating the reproductive toxicity of DCA in males and females. Neurologic symptoms and morphologic changes in the nervous system have been reported in humans, dogs, and rats. (L2086)
Expositionspfade	Ingestion
Toxizitätsübersicht	The dichloroacetate ion stimulates the activity of the enzyme pyruvate dehydrogenase by inhibiting the enzyme pyruvate dehydrogenase kinase. Thus, it decreases lactate production by shifting the metabolism of pyruvate from fermentation towards oxidation in the mitochondria. (Wikipedia)
Carcinogen Classification	2B, possibly carcinogenic to humans. (L135)
Toxicity Data	ORAL (LD50): Acute: 2820 mg/kg [Rat]DERMAL (LD50): Acute: 510 mg/kg [Rabbit]