13551-87-6COCC(O)Cn1ccnc1[N+](=O)[O-]OBBCSXFCDPPXOL-UHFFFAOYSA-NMisonidazole is an organic molecular entity.
13551-87-6、95120-44-8DTXSID80864420CHEMBL42161CHEBI:230671Water 8 (mg/mL)
Methanol 70 (mg/mL)
Ethanol 10 (mg/mL)
Chloroform 10 (mg/mL)
Acetone 50 (mg/mL)
Ethyl acetate 8 (mg/mL)
Bulk: Protected from light, a sample stored for 90 days at 60 °C showed no decomposition (UV or TLC). Exposed to light, a sample at room temperature showed 3% decomposition after 90 days. Solution: A solution in 0.1 N HCl showed no decomposition after 4 days. As a 2% solution at room temperature with and without light, the compound is also stable for at least 4 days. When kept in the refrigerator for 15 days <1% decomposition occurs (TLC).
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Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Rat(po): LD50: 2131 mg/kg
Mouse(po): LD50: 1869 mg/kg
Mouse(ip): LD50: 1340 mg/kg
Mouse(sc): LD50: 1414 mg/kg
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Substances that are destructive to protozoans.
Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.
BeschreibungMisonidazole is a nitroimidazole with radiosensitizing and antineoplastic properties. Nitroimidazoles, including misonidazole, specifically accumulate as nitro anion radicals and their metabolites in hypoxic cells. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells. Misonidazole and derivatives, including fluoromisonidazole, are used in the imaging of hypoxic regions in tumors and in the cardiovascular system.
VerwendenAntiprotozoal (Trichomonas).
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