HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Clotiazepam
Rise · Rize · Rizen · Clozan · Tienor · Y 6047 · Trecalmo · Veratran
Identifikatoren & physikalische Daten
| CAS No. | 33671-46-4 |
|---|---|
| Summenformel | C16H15ClN2OS |
| Durchschnittliche Molmasse | 318,8 g/mol |
| Monoisotopische Masse | 318,059362 g/mol |
| SMILES | CCc1cc2c(s1)N(C)C(=O)CN=C2c1ccccc1Cl |
| InChIKey | CHBRHODLKOZEPZ-UHFFFAOYSA-N |
| PubChem CID | 2811 |
| ChEMBL | CHEMBL1697737 |
| ChEBI | CHEBI:31425 |
| EC No. | 251-627-3 |
| DTXSID | DTXSID0022852 |
| Lokaler Name | Clotiazepam |
Chemische & physikalische Eigenschaften
| XLogP | 3,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 60,9 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 21 |
| Formalladung | 0 |
| Komplexität | 442 |
| Arzneimittel | DEA NFLIS-Drug Category -> BenzodiazepinesDEA Schedule IV Controlled Substance -> DepressantsPharmaceuticals -> Listed in ZINC15Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds |
| LogP (Verteilungskoeffizient) | 3.183.35 |
| Löslichkeit | 5.37e-03 g/LDMF: 15 mg/mlDMSO: 15 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| Human Drugs | Breast FeedingLactationMilk, HumanHypnotics and SedativesAnti-Anxiety AgentsBenzodiazepinesPharmaceuticals |
| Schmelzpunkt | 105-106118 - 120 °C105-106° |
| Physical Description | Solid |
| Siedepunkt | 523.7±50.0 °C(Predicted) |
| Dichte | 1.1625 (rough estimate) |
| Brechungsindex | 1.6100 (estimate) |
| Aggregatzustand | A crystalline solid |
| pKa (Säurekonstante) | 2.36±0.20(Predicted) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P261, P263, P264, P270, P271, P280, P301+P317, P304+P340, P318, P319, P330, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | DEA schedule IV controlled substance |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Treatment | General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended. |
| Gesundheitliche Auswirkungen | They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease. |
| Expositionspfade | Oral |
| Toxizitätsübersicht | Clotiazepam acts at the benzodiazepine receptors (BZD). This agonizes the action of GABA, increasing the frequency of opening of the channel chlorinates and penetration of the ions chlorinates through the ionophore. Increase in membrane polarization decreases the probability of discharge of neurons. |
Anwendungen & Verwendung
Verwenden
A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to be nzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.