Cholinhydroxid

Choline, hydroxide

HCID 31255CAS 123-41-1

Grundinformationen

Standard-SMILES
C[N+](C)(C)CCO.[OH-]
InChIKey
KIZQNNOULOCVDM-UHFFFAOYSA-M
Summenformel
C5H15NO2
Durchschnittliche Molmasse
121,18 g/mol
Monoisotopische Masse
121,11027872

Namen und Bezeichner

Bevorzugter Name
Choline, hydroxide
IUPAC
2-hydroxyethyl(trimethyl)azanium hydroxide
Lokaler Name
Cholinhydroxid
Englischer Name
Choline hydroxide
Summenformel
C5H15NO2
Molmasse
121.18

Namen und Synonyme

CHOLINE HYDROXIDE123-41-1GossypineLuridine2-Hydroxy-N,N,N-trimethylethanaminium hydroxideSinkalinSinkaline(2-Hydroxyethyl)trimethylammonium hydroxideDTXSID9047467CHOLINE, HYDROXIDETrimethyl(2-hydroxyethyl)ammonium hydroxideEthanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide
Weitere Namen anzeigen
CHOLINECholine hydroxide solutionvidineCHOLINE BASECholine hydroxide, 45 wt.% aqueous solution, stabilized, pureSKL1388SKL1600
(beta-Hydroxyethyl)trimethylammonium hydroxideDTXCID7027467Hydroxide, CholineRefChem:125755204-625-1SincalineBursineFagine

Datenbank-Bezeichner

CAS
123-41-1
PubChem CID
31255
DTXSID
DTXSID9047467
ChEMBL
CHEMBL3187547
UNII
7THJ3EG9SY
EC Number
204-625-1

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
21,2 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
2
Schwere Atome
8

Experimentelle und physikochemische Eigenschaften

Physical Description · 2 Einträge

Liquid

45% aqueous solution: Brown viscous liquid; [Acros Organics MSDS]

Physikochemische Eigenschaften

Schmelzpunkt
236 · 236~239℃
Dichte
1.09 g/mL · 1.09 g/mL at 20 °C
Dampfdruck
28.284 hPa · 28.284hPa at 25℃
Brechungsindex
20 · n20/D 1.4304
Flammpunkt
92 °F · 92 °F
storage temp.
2 · Inert atmosphere,2-8°C

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

Danger

H314 (99.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation];H318 (69%): Causes serious eye damage [Danger Serious eye damage/eye irritation];H335 (20.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H373 (20.2%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 352 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory Information · 4 Einträge

Chemical: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 24-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/5289

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards SummaryCauses convulsions and dyspnea in intravenous lethal-dose studies of mice (LD50 = 21.4 mg/kg); [RTECS] 45% aqueous solution: Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Acros Organics MSDS]
Hazard Classes and CategoriesSkin Corr. 1B (99.7%);Eye Dam. 1 (69%);STOT SE 3 (20.5%);STOT RE 2 (20.2%)

Toxikologische Informationen

Adverse EffectsDermatotoxin - Skin burns.;Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Regulatorische Informationen

Regulatory Information · 4 Einträge

Chemical: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 24-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/5289

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Sicherheitsdaten

F
8-9-23
wgk
1
tsca
TSCA listed
ridadr
UN 3286 3/PG 2
hs_code
29231000
RTECS-Nr.
GA4025500

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 2 Einträge

Endogenous factors or drugs that increase the transport and metabolism of LIPIDS including the synthesis of LIPOPROTEINS by the LIVER and their uptake by extrahepatic tissues.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms.

Verwendung und Herstellung

U.S. Production2023: 10,000,000 - <50,000,000 lb;2022: 10,000,000 - <50,000,000 lb;2021: 25,000,000 - <40,000,000 lb;2020: 25,000,000 - <40,000,000 lb
Consumer UsesSolids separation (precipitating) agent, not otherwise specified;Intermediate
Industry UsesPlating agent;pH regulating agent;Solids separation (precipitating) agent, not otherwise specified;Intermediate
General Manufacturing Information · 2 Einträge

Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing;Computer and Electronic Product Manufacturing;All Other Chemical Product and Preparation Manufacturing;All Other Basic Organic Chemical Manufacturing;Other (requires additional information)

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (1:1): ACTIVE

Anwendungen

VerwendenCholine hydroxide is used as a precursor molecule for the neurotransmitter acetylcholine, it is involved in several functions including muscle and memory muscle control. It was used as a basic catalyst for aldol condensation reactions.

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
河北创之源生物科技有限公司13012111162
上海遐瑞医药科技有限公司+86-021-61551413 · [email protected]
陕西晨明生物科技有限公司15529026321
Ergänzende Hinweise · 1 Eintrag

DefinitionAn amino alcohol,CH2OHCH2N(CH3)3OH. It occurswidely in living organisms as aconstituent of certain types ofphospholipids– the lecithins andsphingomyelins– and in the neurotransmitteracetylcholine. It issometimes classified as a memberof the vitamin B complex.

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