Choline, hydroxide → HCID 178418366, Verbindung

HRID 3140

Reaktionsgleichung

Reaktionsgleichung von HRID 3140
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]([OH:18])=[C:7]3[C:15](=[O:16])[NH:14][NH:13][C:12](=[O:17])[C:8]3=[N:9][C:10]=2[CH:11]=1.[OH-].[OH:20][CH2:21][CH2:22][N+:23]([CH3:26])([CH3:25])[CH3:24]>CO>[OH:20][CH2:21][CH2:22][N+:23]([CH3:26])([CH3:25])[CH3:24].[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]([OH:18])=[C:7]3[C:15](=[O:16])[NH:14][NH:13][C:12](=[O:17])[C:8]3=[N:9][C:10]=2[CH:11]=1

Komponenten

4

Edukt 2

HCID 31255Choline, hydroxideHCID 178418312HCID 178418312, Verbindung

Produkt 1

HCID 178418366HCID 178418366, VerbindungAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a suspension of 7-bromo-2,3-dihydro-10-hydroxypyridazino[4,5-b]quinoline-1,4-dione (0.600g, 1.95 mM) in methanol (20 mL) was added choline hydroxide (0.24 g, 1.98 mM, 45% solution in methanol). The resulting solution was concentrated and the solid yellow residue was recrystallized from ethanol to provide (0.62 g, 78%) the title compound as yellow crystals, mp 227.5°-228.5° C.

Aufarbeitung

  1. concentrationThe resulting solution was concentrated
  2. customthe solid yellow residue was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-94d9309832e348ba9c46db768414dfd5
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05733910

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