HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methansulfonylchlorid
MSCL · MESYL CHLORIDE · MSC · MSCI · METHYLSULFONYL CHLORIDE · CH3SO2Cl · methanesulfonyl · METHANESULPHONYL CHLORIDE
Identifikatoren & physikalische Daten
| CAS No. | 124-63-0 |
|---|---|
| Summenformel | CH3ClO2S |
| Durchschnittliche Molmasse | 114,55 g/mol |
| Monoisotopische Masse | 113,95422802 g/mol |
| SMILES | CS(=O)(=O)Cl |
| InChIKey | QARBMVPHQWIHKH-UHFFFAOYSA-N |
| PubChem CID | 31297 |
| EC No. | 204-706-1 |
| DTXSID | DTXSID1021615 |
| Lokaler Name | Methansulfonylchlorid |
Chemische & physikalische Eigenschaften
| XLogP | 0,4 |
|---|---|
| Polarare Oberfläche (TPSA) | 42,5 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 5 |
| Formalladung | 0 |
| Komplexität | 95,3 |
| Stoffklassen | Toxic Gases & Vapors -> Acid Halides |
| SpringerMaterials Properties | Schoenflies notation |
| Geruch | Unpleasant odor |
| Dichte | 1.4805 at 18 °C/4 °CRelative density (water = 1): 1.51.4805 @ 18°C1.48 g/mL at 25 °C (lit.) |
| Viscosity | 1.33 centistokes at 25 °C |
| Color/Form | Pale yellow liquid |
| Löslichkeit | Soluble in most organic solventsPractically insoluble in watersoluble in alcohol, etherSolubility in water: reactionChloroform, HexanesMiscible with alcohol, ether and organic solvents. Immiscible with water. |
| Flammpunkt | >110 °C>230 °F |
| Siedepunkt | 62 °C at 18 mm Hg161 °C at 730 mm Hgat 97.3kPa: 161 °C60 °C/21 mmHg (lit.) |
| Decomposition | When heated to decompositionit emits toxic vapors of /sulfur oxides and hydrogen chloride/. |
| Schmelzpunkt | Freezing point: -32 °C-33°C |
| Dampfdichte | 3.9 (Air = 1)Relative vapor density (air = 1): 4.0 |
| Dampfdruck | 3.001-8.9hPa at 20-25℃ |
| Brechungsindex | n20/D 1.452(lit.) |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | Liquid |
| Farbe | Clear |
| Geruch | Unpleasant odor |
| Merck | 14,5955 |
| BRN | 506297 |
| Henry-Konstante | 2.2×10-1 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stabilität | Moisture Sensitive |
| InChI | 1S/CH3ClO2S/c1-5(2,3)4/h1H3 |
| InChIKey | QARBMVPHQWIHKH-UHFFFAOYSA-N |
| SMILES | CS(Cl)(=O)=O |
| LogP (Verteilungskoeffizient) | -0.78-1.27 at 25℃ |
| Oberflächenspannung | 72.5mN/m at 1.1g/L and 21℃ |
| CAS Datenbank | 124-63-0(CAS DataBase Reference) |
| NIST chemische Informationen | Methanesulfonyl chloride(124-63-0) |
| EPA chemische Informationen | Methanesulfonyl chloride (124-63-0) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH290 (47.5%): May be corrosive to metals [Warning Corrosive to Metals]P234, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P320, P321, P330, P333+P317, P361+P364, P362+P364, P363, P390, P403+P233, P405, P406, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 314 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H301: Toxic if swallowed [Danger Acute toxicity, oral] |
|---|---|
| Hazards Identification | Toxic/poison by inhalation (TIH/PIH) |
| Regulatorische Informationen | Chemical: Methanesulfonyl chlorideMethanesulfonyl chloride is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methanesulfonyl chloride are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)SP - indicates a substance that is identified in a proposed Significant New Use Rule.Status: Active Update: 10-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/13541Methanesulphonyl chloride: HSNO Approval: HSR004556 Approved with controls |
| DOT-Kennzeichnung | Poison Inhalation Hazard Corrosive |
| Brandgefahren | Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:· Combustible material: may burn but does not ignite readily.Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Gesundheitsgefahren | Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:· TOXIC and/or CORROSIVEinhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. |
| Gefahrenübersicht | Highly corrosive to skin[Quick CPC] It is tear drawing and corrosive to the skin and respiratory tract |
Anwendungen & Verwendung
Verwenden
Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. Beckmann rearrangement. It is an electrophile and acts as a source of CH3SO2+ group. It is also used to prepare beta-chloro sulfones, methanesulfonamide and heterocyclic compounds containing five membered sultones.