Grundinformationen
- Standard-SMILES
CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O- InChIKey
ULGZDMOVFRHVEP-UHFFFAOYSA-N- Summenformel
- C37H67NO13
- Durchschnittliche Molmasse
- 733,9 g/mol
- Monoisotopische Masse
- 733,4612412
Überblick
See also: Erythromycin (annotation moved to); Buserelin (annotation moved to); Erythromycin ethyl succinate (annotation moved to) ... View More ...
Namen und Bezeichner
- Bevorzugter Name
- 6-((4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-((5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
- IUPAC
- 6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
- Englischer Name
- Erythromycin
- Summenformel
- C37H67NO13
- Molmasse
- 733.93
Namen und Synonyme
Weitere Namen anzeigen
Datenbank-Bezeichner
- CAS
114-07-8- PubChem CID
- 3255
- DTXSID
DTXSID90859206- ChEMBL
CHEMBL1671887
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,7
- Polarare Oberfläche (TPSA)
- 194 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 14
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 51
- Formalladung
- 0
- Komplexität
- 1.180
Experimentelle und physikochemische Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 133 °C · 133 °C
- Siedepunkt
- 719.69 °C · 719.69°C (rough estimate)
- Dichte
- 1.1436 · 1.1436 (rough estimate)
- Brechungsindex
- -74 ° · -74 ° (C=2, EtOH)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- ethanol: soluble
- Aggregatzustand
- powder
- pka
- 8.8 · 8.8(at 25℃)
- Farbe
- white to faint yellow
- Biologische Quelle
- Streptomyces erythreus
- Wasserlöslichkeit
- 2 mg/ml · Soluble in water at 2mg/ml
- Merck
- 14 · 14,3681
- BRN
- 8183758 · 8183758
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- HIYRERIGRWIODP-PNFGZDISSA-N
- EPA chemische Informationen
- Erythromycin (114-07-8)
Sicherheit und Regulatorisches
Sicherheitsdaten
- F
- 3-4.3-10
- wgk
- 2
- hs_code
- 29415000
- RTECS-Nr.
- KF4375000
- risk_code
- 42/43-36/37/38
- Toxizität
- LD50 oral in rat: 4600mg/kg
- hazard_code
- Xn,Xi
- safety_code
- 45-37-24-36-26-24/25
- hazard_class
- 3
- Speicherklasse
- 11 - Combustible Solids
- Giftige Stoffe Daten
- 114-07-8(Hazardous Substances Data)
Chemie und Industrie
Anwendungen
BeschreibungErythromycin ethyl succinate is a mixed double ester pro-drug in which one carboxyl of succinic acid esterifies the C-2′ hydroxyl of erythromycin and the other ethanol. This pro-drug frequently is used in an oral suspension for pediatric use largely to mask the bitter taste of the drug. Film-coated tablets also are used to deal with this. Some cholestatic jaundice is associated with the use of EES.
VerwendenErythromycin A is a 14-membered macrocyclic lactone with broad spectrum antibiotic activity, isolated from Saccharopolyspora erythraea (formerly Streptomyces erythreus) in 1952. Erythromycin is one of only a handful of microbial metabolites to have profoundly shaped the treatment of bacterial disease in the last 50 years. Erythromycin has given rise to new generations of semi-synthetic derivatives with improved stability and potency. Our product has been HPLC-purified to remove contaminants and degradation products.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Nachgelagerte Produkte
Anbieter50 Anbieter
Ergänzende Hinweise
DefinitionAn antibiotic produced by growth of Streptomyces erythreus Waksman. It is effective against infections caused by Gram-positive bacteria, including some β-hemolytic streptococci, pneumococci, and staphylococci.
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