HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 3375Erstellt: 4. November 2026
Flumetason
flumetasone · fluvet · FLUCORT · rs-2177 · ANIPRIME · anaprime · methagon · NSC-54702
https://huagongshe.com/de/chemical/3375
Identifikatoren & physikalische Daten
| CAS No. | 2135-17-3 |
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| Summenformel | C22H28F2O5 |
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| Durchschnittliche Molmasse | 410,5 g/mol |
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| Monoisotopische Masse | 410,19048031 g/mol |
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| SMILES | CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO |
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| InChIKey | WXURHACBFYSXBI-UHFFFAOYSA-N |
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| PubChem CID | 3375 |
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| ChEMBL | CHEMBL2007346 |
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| DTXSID | DTXSID30859700 |
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| Lokaler Name | Flumetason |
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Chemische & physikalische Eigenschaften
| XLogP | 1,9 |
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| Polarare Oberfläche (TPSA) | 94,8 |
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| H-Brücken-Donoren | 3 |
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| H-Brücken-Akzeptoren | 7 |
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| Frei drehbare Bindungen | 2 |
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| Schwere Atome | 29 |
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| Formalladung | 0 |
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| Komplexität | 839 |
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| Schmelzpunkt | 237-240°C |
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| Siedepunkt | 569.8±50.0 °C(Predicted) |
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| Dichte | 1.1621 (estimate) |
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| Lagerbedingungen | 2-8°C |
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| Löslichkeit | acetic acid: soluble10mg/mL1mg/L(20 ºC) |
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| Aggregatzustand | solid |
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| pKa (Säurekonstante) | 11.98±0.70(Predicted) |
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| Farbe | white |
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| Merck | 14,4138 |
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| InChIKey | WXURHACBFYSXBI-GQKYHHCASA-N |
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| SMILES | C1(=O)C=C2[C@](C)(C=C1)[C@]1(F)[C@]([H])([C@@]3([H])[C@@](C[C@@H]1O)(C)[C@@](O)(C(=O)CO)[C@H](C)C3)C[C@@H]2F |
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| CAS Datenbank | 2135-17-3(CAS DataBase Reference) |
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Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
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| Zollcode | 29144000 |
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| RTECS-Nr. | TU3832000 |
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| R-Sätze (R) | 40 |
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| Gefahrensymbole | Xn |
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| Sicherheitshinweise (S) | 22-36 |
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| Lagerklasse | 11 - Combustible Solids |
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| Gefahrenklasse | Carc. 2 |
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Anwendungen & Verwendung
Beschreibung
Flumethasone is an agonist of glucocorticoid and mineralocorticoid receptors with EC50 values of 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors. In vitro, it inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines at a concentration of 100 nM. Flumethasone (5 mg per animal) decreases tumor necrosis factor (TNF) production ex vivo in blood cells collected by bronchoalveolar lavage (BAL) from calves with experimentally-induced local lung inflammation. It also inhibits phytohemagglutinin-induced delayed hypersensitivity in calf skin. In vivo, flumethasone (5 μM) impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in zebrafish.
