Grundinformationen
- Standard-SMILES
CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3OC(CN)=CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O- InChIKey
URWAJWIAIPFPJE-YFMIWBNJSA-N- Summenformel
- C19H37N5O7
- Durchschnittliche Molmasse
- 447,5 g/mol
Überblick
Sisomycin is an amino cyclitol glycoside, an aminoglycoside antibiotic, a beta-L-arabinoside and a monosaccharide derivative.
Namen und Bezeichner
- Bevorzugter Name
- Sisomicin
- IUPAC
- (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
Namen und Synonyme
sisomicinRickamicin32385-11-8SisomycinSissomicinAntibiotic 66-40SisomicinaSisomicineAntibiotic 6640SisomicinumSch 13475Dehydrogentamicin Cla
Weitere Namen anzeigen
X55XSL74YQ4,5 DehydrogentamicinSch13475CHEBI:9169(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diolD-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-Sizomycin(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yloxy]-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside
Datenbank-Bezeichner
- CAS
32385-11-8- PubChem CID
- 36119
- ChEMBL
CHEMBL221886- ChEBI
CHEBI:9169- UNII
- X55XSL74YQ
- EC Number
- 251-018-2
- Nikkaji
- J342.544D
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -5,1
- Polarare Oberfläche (TPSA)
- 214 Ų
- H-Brücken-Donoren
- 8
- H-Brücken-Akzeptoren
- 12
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 31
- Formalladung
- 0
- Komplexität
- 643
Experimentelle und physikochemische Eigenschaften
Drugs
Pharmaceuticals -> Antibiotics
Pharmaceuticals -> Listed in ZINC15
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Danger
H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
P203, P261, P271, P280, P302+P352, P304+P340, P317, P318, P321, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationREACH registered substance: Sisomicin (EC: 251-018-2)
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Chemie und Industrie
Pharmakologische Informationen
ATC Code
J - Antiinfectives for systemic use
QJ - Antiinfectives for systemic use
MeSH Pharmacological Classification
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Substances that inhibit the growth or reproduction of BACTERIA.
Zugehörige Reaktionen
2
Verknüpfte Notizen
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