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Sisomicin
SISOMYCIN · Siseptin · Sch 13475 · Sisomicin · Rickamicin · Sisomicin base · Antibiotic 6640 · Sisomicin (8CI)
Identifikatoren & physikalische Daten
| CAS No. | 32385-11-8 |
|---|---|
| Summenformel | C19H37N5O7 |
| Durchschnittliche Molmasse | 447,5 g/mol |
| SMILES | CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3OC(CN)=CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O |
| InChIKey | URWAJWIAIPFPJE-YFMIWBNJSA-N |
| PubChem CID | 36119 |
| ChEMBL | CHEMBL221886 |
| ChEBI | CHEBI:9169 |
| EC No. | 251-018-2 |
| Lokaler Name | Sisomicin |
Chemische & physikalische Eigenschaften
| XLogP | -5,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 214 |
| H-Brücken-Donoren | 8 |
| H-Brücken-Akzeptoren | 12 |
| Frei drehbare Bindungen | 6 |
| Schwere Atome | 31 |
| Formalladung | 0 |
| Komplexität | 643 |
| Arzneimittel | Pharmaceuticals -> AntibioticsPharmaceuticals -> Listed in ZINC15 |
| Schmelzpunkt | 80-93°C |
| Siedepunkt | 556.56°C (rough estimate) |
| Dichte | 1.2777 (rough estimate) |
| Brechungsindex | 1.7600 (estimate) |
| Lagerbedingungen | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Löslichkeit | Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly, |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 13.29±0.70(Predicted) |
| Farbe | Pale Yellow to Yellow |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]P203, P261, P271, P280, P302+P352, P304+P340, P317, P318, P321, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | REACH registered substance: Sisomicin (EC: 251-018-2) |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Alarmwort | Achtung |
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H312 |
Anwendungen & Verwendung
Beschreibung
Sisomicin was found in the culture broth of Micromonospora inyoensis by Schering-Plough Co. in 1970, following the discovery of gentamicin by the same research group. The structure and activity of sisomicin are very similar to those of gentamicin C1a, the major component of the gentamicin complex. Sisomicin shows stronger bacterial activity and lower renal and ototoxicity than gentamicin C1a .
Verwenden
Sisomicin is an Antibacterial. Gentamicin-like aminoglycoside antibiotic; has broad spectrum antibiotic activity.