4-(2-Aminopropyl)phenol

Hydroxyamfetamine

HCID 3651CAS 103-86-6

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Grundinformationen

Standard-SMILES: CC(N)Cc1ccc(O)cc1
InChIKey: GIKNHHRFLCDOEU-UHFFFAOYSA-N
Summenformel: C9H13NO
Durchschnittliche Molmasse: 151,21 g/mol
Monoisotopische Masse: 151,09971404

Überblick

4-(2-aminopropyl)phenol is a member of amphetamines.

Namen und Bezeichner

Bevorzugter Name: Hydroxyamfetamine
IUPAC: 4-(2-aminopropyl)phenol
Lokaler Name: 4-(2-Aminopropyl)phenol
Englischer Name: 4-(2-aminopropyl)phenol
Summenformel: C9H13NO
Molmasse: 151.21

Namen und Synonyme

4-(2-Aminopropyl)phenolhydroxyamphetamine103-86-6HydroxyamfetamineNorveritolPulsotonOxamphetaminiumOksamfetaminOxamfetaminParedrinexNov-Pholedrinp-(2-Aminopropyl)phenol

Weitere Namen anzeigen

Norpholedrinep-Hydroxyamphetamine.alpha.-MethyltyraminePhenol,4-(2-aminopropyl)-Dl-p-(2-aminopropyl)phenol4-Hydroxy-.alpha.-methylphenethylamine2-(4-Hydroxyphenyl)-1-methylethylamine

Phenol, p-(2-aminopropyl)-DL-p-Hydroxyamphetamine1-p-Hydroxyphenyl-2-propylaminedl-4-hydroxyamphetamine2-Amino-1-(p-hydroxyphenyl)propaneNSC 170995Hydroxyamfetamine [INN]Hidroxianfetamina

Datenbank-Bezeichner

CAS: 103-86-6
PubChem CID: 3651
DTXSID: DTXSID3023134
ChEMBL: CHEMBL1546
ChEBI: CHEBI:103855
UNII: FQR280JW2N
EC Number: 203-152-8
Nikkaji: J182.169E

Eigenschaften

Berechnete Struktureigenschaften

XLogP: 1,4
Polarare Oberfläche (TPSA): 46,3 Å²
H-Brücken-Donoren: 2
H-Brücken-Akzeptoren: 2
Frei drehbare Bindungen: 2
Schwere Atome: 11
Formalladung: 0
Komplexität: 108

Experimentelle und physikochemische Eigenschaften

DrugsDEA NFLIS-Drug Category -> Phenethylamines (Amphetamines) (S)

Physikochemische Eigenschaften

Schmelzpunkt: 125 · 125-126 °C
Siedepunkt: 279.2 · 279.2±15.0 °C(Predicted)
Dichte: 1.07 · 1.070±0.06 g/cm3(Predicted)
storage temp.: -20 °C · Store at -20°C
Aggregatzustand: Solid
pka: 9.83 · 9.83±0.15(Predicted)
Farbe: White to off-white

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Sicherheitsdaten

Toxizität: LDLo intravenous in rat: 100mg/kg

Chemie und Industrie

Pharmakologische Informationen

Protein BindingIntended for local use only (ophthalmic use).

Mechanism of ActionHydroxyamphetamine hydrobromide is an indirect acting sympathomimetic agent which causes the release of norepinephrine from adrenergic nerve terminals, resulting in mydriasis.

Metabolism/Metabolites · 2 Einträge

Intended for local use only (ophthalmic use).

4-Hydroxyamphetamine is a known human metabolite of Amphetamine.

FDA Pharmacological Classification · 5 Einträge

FQR280JW2N

HYDROXYAMPHETAMINE

Mechanisms of Action [MoA] - Adrenergic Agonists

Established Pharmacologic Class [EPC] - Adrenergic Receptor Agonist

Hydroxyamphetamine is an Adrenergic Receptor Agonist. The mechanism of action of hydroxyamphetamine is as an Adrenergic Agonist.

Absorption, Distribution and Excretion · 4 Einträge

Intended for local use only (ophthalmic use).

Tissue LocationsKidney