Halofantrin

Halofantrine

HCID 37393CAS 66051-74-9
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Grundinformationen

Standard-SMILES
CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12
InChIKey
FOHHNHSLJDZUGQ-UHFFFAOYSA-N
Summenformel
C26H30Cl2F3NO
Durchschnittliche Molmasse
500,4 g/mol
Monoisotopische Masse
499,1656546

Überblick

3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)-9-phenanthrenyl]-1-propanol is a member of phenanthrenes.

Namen und Bezeichner

Bevorzugter Name
Halofantrine
IUPAC
3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol
Lokaler Name
Halofantrin
Englischer Name
HALOFANTRINE
Summenformel
C26H30Cl2F3NO
Molmasse
500.42

Namen und Synonyme

Halofantrine69756-53-2Halofantrinum3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol3-(Dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl)propan-1-olQ2OS4303HZDL-WR-171669DTXSID0023119WR-171699RefChem:783364DTXCID403119P01BX01
Weitere Namen anzeigen
HalofanWR-171669SKF-102886Halofantrine D18HALOFANTRINE USP/EP/BPHalofantrine hydrochloride CRS3-(Dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)-phenanthren-9-yl)propan-1-ol1，3-Dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol3-DIBUTYLAMINO-1-(1,3-DICHLORO-6-TRIFLUOROMETHYL-PHENANTHREN-9-YL)-PROPAN-1-OL HCL
274-104-1Halofantrine, (-)-Halofantrinum [INN-Latin]Halofantrina [INN-Spanish]66051-76-1dl-WR 171669(+)-HalofantrineHalofantrine (INN)

Datenbank-Bezeichner

CAS
66051-74-9、66051-76-1、69756-53-2
PubChem CID
37393
DTXSID
DTXSID0023119
ChEMBL
CHEMBL1107
ChEBI
CHEBI:94392
UNII
Q2OS4303HZ
EC Number
274-104-1
Nikkaji
J18.879D

Eigenschaften

Berechnete Struktureigenschaften

XLogP
8,6
Polarare Oberfläche (TPSA)
23,5 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
5
Frei drehbare Bindungen
10
Schwere Atome
33

Experimentelle und physikochemische Eigenschaften

DrugsPharmaceuticals -> Antiparasitic products, insecticides and repellents -> Antiprotozoals
LogP8.9
Solubility1.11e-04 g/L
Human DrugsBreast Feeding; Lactation; Milk, Human; Anti-infective Agents; Antiparasitic Agents; Antimalarials; Antiprotozoal Agents
Physical DescriptionSolid

Physikochemische Eigenschaften

Dichte
1.244 · 1.244±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.
2 · 2-8°C
Wasserlöslichkeit
0.59 mg/L · 0.59mg/L(37 ºC)

Sicherheit und Regulatorisches

Toxikologische Informationen

Drug Induced Liver Injury · 4 Einträge

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

Halofantrine

DILI Positive

DOI:10.1016/j.drudis.2019.09.022

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Chemie und Industrie

Pharmakologische Informationen

ATC CodeP - Antiparasitic products, insecticides and repellents
Protein Binding60-70%;
PharmacodynamicsHalofantrine is a synthetic antimalarial which acts as a blood schizonticide. It is effective against multi drug resistant (including mefloquine resistant) <i>P. falciparum</i> malaria.
Mechanism of ActionThe mechanism of action of Halofantrine may be similar to that of chloroquine, quinine, and mefloquine; by forming toxic complexes with ferritoporphyrin IX that damage the membrane of the parasite.
Biological Half-Life6-10 days
Metabolism/MetabolitesHepatic

Anwendungen

BeschreibungHalofantrine is an orally-active blood schizonticide reportedly highly effective in the treatment of fulcipurum malaria and other types of parasitemia. Cure rate is claimed to be over 95%.

Vor- und nachgelagerte Produkte

Anbieter20 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]

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