HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Halofantrin
Halofan · WR-171669 · SKF-102886 · HALOFANTRINE · Halofantrine D18 · HALOFANTRINE USP/EP/BP · Halofantrine hydrochloride CRS · 3-(Dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)-phenanthren-9-yl)propan-1-ol
Identifikatoren & physikalische Daten
| CAS No. | 66051-74-9 |
|---|---|
| Summenformel | C26H30Cl2F3NO |
| Durchschnittliche Molmasse | 500,4 g/mol |
| Monoisotopische Masse | 499,1656546 g/mol |
| SMILES | CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12 |
| InChIKey | FOHHNHSLJDZUGQ-UHFFFAOYSA-N |
| PubChem CID | 37393 |
| ChEMBL | CHEMBL1107 |
| ChEBI | CHEBI:94392 |
| EC No. | 274-104-1 |
| DTXSID | DTXSID0023119 |
| Lokaler Name | Halofantrin |
Chemische & physikalische Eigenschaften
| XLogP | 8,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 23,5 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 10 |
| Schwere Atome | 33 |
| Formalladung | 0 |
| Komplexität | 584 |
| Arzneimittel | Pharmaceuticals -> Antiparasitic products, insecticides and repellents -> Antiprotozoals |
| LogP (Verteilungskoeffizient) | 8.9 |
| Löslichkeit | 1.11e-04 g/L0.59mg/L(37 ºC) |
| Human Drugs | Breast FeedingLactationMilk, HumanAnti-infective AgentsAntiparasitic AgentsAntimalarialsAntiprotozoal Agents |
| Physical Description | Solid |
| Dichte | 1.244±0.06 g/cm3 (20 ºC 760 Torr) |
| Lagerbedingungen | 2-8°C |
Sicherheit & Vorschriften
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)HalofantrineDILI PositiveDOI:10.1016/j.drudis.2019.09.022 |
|---|---|
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
Anwendungen & Verwendung
Beschreibung
Halofantrine is an orally-active blood schizonticide reportedly highly effective in the treatment of fulcipurum malaria and other types of parasitemia. Cure rate is claimed to be over 95%.