Flunixin (HCID 38081)

Namen und Bezeichner

Bevorzugter Name: Flunixin
IUPAC: 2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
Englischer Name: FLUNIXIN MEGLUMINE
Summenformel: C14H11F3N2O2
Molmasse: 296.24

Namen und Synonyme

FLUNIXIN38677-85-9FlunixineFlunixinoSch 14714FlunixinumSCH-14714CHEBI:761382-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid356IB1O4002(2'-Methyl-3'-trifluoromethylanilino)nicotinic acidDTXSID4048565

Weitere Namen anzeigen

BANAMINEBUTANIXINFlunixin VETRANALFlunixin MeglimineC13726900 FlunixinFlunixin in methanolFlunixinMeglumineBasedisodium salt hydrateFLUNIXIN MEGLUMINE SALT

3-Pyridinecarboxylic acid, 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxylic acid2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid3-Pyridinecarboxylic acid, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-2-(2-methyl-3-(trifluoromethyl)anilino)pyridine-3-carboxylic acidBanamine-SBanamine TransdermalRefChem:57817

Datenbank-Bezeichner

CAS: 38677-85-9
PubChem CID: 38081
DTXSID: DTXSID4048565
ChEMBL: CHEMBL1617398
ChEBI: CHEBI:76138
UNII: 356IB1O400
EC Number: 609-571-6
Nikkaji: J15.816J

Eigenschaften

Berechnete Struktureigenschaften

XLogP: 4,1
Polarare Oberfläche (TPSA): 62,2 Å²
H-Brücken-Donoren: 2
H-Brücken-Akzeptoren: 7
Frei drehbare Bindungen: 3
Schwere Atome: 21
Formalladung: 0
Komplexität: 376

Experimentelle und physikochemische Eigenschaften

Collision Cross Section159.1 Å² [M+H]+ [CCS Type: TW]

Physikochemische Eigenschaften

Schmelzpunkt: 136.6 · 136.6-137.4 °C
Siedepunkt: 378.7 · 378.7±42.0 °C(Predicted)
Dichte: 1.403 · 1.403±0.06 g/cm3(Predicted)
Löslichkeit: 2 O: · H2O: freely soluble
Aggregatzustand: solid
pka: 5.82 · 5.82(at 25℃)
Farbe: off-white
Stabilität: Stable. Incompatible with strong bases, strong oxidizing agents.
Major Application: forensics and toxicologypharmaceutical (small molecule)
InChI: 1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)
InChIKey: NOOCSNJCXJYGPE-UHFFFAOYSA-N
SMILES: Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F
CAS Datenbank: 38677 · 38677-85-9(CAS DataBase Reference)
EPA chemische Informationen: 3 · 3-Pyridinecarboxylic acid, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]- (38677-85-9)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

Danger

H301 (93.3%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 2 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory InformationFlunixin: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazard Classes and CategoriesAcute Tox. 3 (93.3%)

Regulatorische Informationen

Regulatory InformationFlunixin: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Sicherheitsdaten

wgk: 3
ridadr: UN2811 6.1/PG 3
hs_code: 2933399990
RTECS-Nr.: LZ4367000
risk_code: 36/37/38-22
hazard_code: Xi,Xn
safety_code: 26-36
Speicherklasse: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

Chemie und Industrie

Pharmakologische Informationen

ATC CodeQM - Musculo-skeletal system；QM01 - Antiinflammatory and antirheumatic products；QM01A - Antiinflammatory and antirheumatic products, non-steroids；QM01AG - Fenamates；QM01AG90 - Flunixin

MeSH Pharmacological Classification · 2 Einträge

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Drugs that are used to reduce body temperature in fever.

Verwendung und Herstellung

Use Classification · 2 Einträge

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Anwendungen

VerwendenCyclooxigenase inhibitor. Anti-inflammatory; analgesic; antipyretic

Anbieter47 Anbieter

武汉欣扬瑞和化学科技有限公司18171205315; 18171205315 · [email protected]

陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]

LGM Pharma1-(800)-881-8210 · [email protected]

Syntechem Co.,Ltd[email protected]

梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]

Ergänzende Hinweise · 1 Eintrag

DefinitionChEBI: A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; sed in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs.