Monensin, Mononatriumsalz
4-(2-(2-Ethyl-5'-(6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl)-3'-methyl(2,2'-bioxolan)-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro(4.5)decan-7-yl)-3-methoxy-2-methylpentanoic acid
Grundinformationen
- CAS
22373-78-0- Standard-SMILES
CCC1(C2OC(C3OC(O)(CO)C(C)CC3C)CC2C)CCC(C2(C)CCC3(CC(O)C(C)C(C(C)C(OC)C(C)C(=O)O)O3)O2)O1- InChIKey
GAOZTHIDHYLHMS-UHFFFAOYSA-N- Summenformel
- C36H62O11
- Durchschnittliche Molmasse
- 670,9 g/mol
- Monoisotopische Masse
- 670,42921279
Überblick
monensin has been reported in Streptomyces cinnamonensis with data available.
Namen und Bezeichner
- Bevorzugter Name
- 4-(2-(2-Ethyl-5'-(6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl)-3'-methyl(2,2'-bioxolan)-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro(4.5)decan-7-yl)-3-methoxy-2-methylpentanoic acid
- IUPAC
- 4-[2-[5-ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoic acid
- Lokaler Name
- Monensin, Mononatriumsalz
- Englischer Name
- Monensin sodium salt
- Summenformel
- C36H63NaO12
- Molmasse
- 710.87
Namen und Synonyme
DTXSID108601974-(2-(2-Ethyl-5'-(6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl)-3'-methyl(2,2'-bioxolan)-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro(4.5)decan-7-yl)-3-methoxy-2-methylpentanoic acid4-(2-{2-Ethyl-5'-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3'-methyl[2,2'-bioxolan]-5-yl}-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-methoxy-2-methylpentanoic acidRefChem:1069773DTXCID60197066Coban (Salt/Mix)Romensin (Salt/Mix)Rumensin (Salt/Mix)MLS006011801SCHEMBL1143131CHEMBL4788880GAOZTHIDHYLHMS-UHFFFAOYSA-N
Weitere Namen anzeigen
CobanRUMENSINCoban45SodiummonensinMonomycin sodiumMonensinsodiumsalMONENSINSODIUM,USPMonensin sodium 40%Monensin sodium saltPreviouscas:22136-43-2
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 4,2
- Polarare Oberfläche (TPSA)
- 153 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 11
- Frei drehbare Bindungen
- 10
- Schwere Atome
- 47
- Formalladung
- 0
- Komplexität
- 1.110
Physikochemische Eigenschaften
- Schmelzpunkt
- 267 · 267-269 C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 50 mg/ml · Soluble in methanol at 50mg/ml
- Aggregatzustand
- Off-white to beige solid
- Farbe
- White
- BRN
- 4122200 · 4122200
- Stabilität
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- XOIQMTLWECTKJL-BEMBKCOJSA-M
- LogP
- 3.716 · 3.716 (est)
- EPA chemische Informationen
- Monensin, monosodium salt (22373-78-0)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 3462 6.1/PG 2
- hs_code
- 29419090
- RTECS-Nr.
- JH2830000
- risk_code
- 25-26/27/28
- hazard_code
- T,T+
- safety_code
- 36/37/39-45-22
- hazard_class
- 6.1(a)
- packing_group
- II
- Speicherklasse
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- Hazard Classifications
- Acute Tox. 2 OralAquatic Chronic 2Eye Irrit. 2STOT RE 2
Chemie und Industrie
Anwendungen
BeschreibungMonensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.
VerwendenMonensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.
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国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18062128043 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
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