HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 4341Erstellt: 3. November 2026
N-acetyl Leukotriene E4
N-AC-LTE4 · N-AcetylLTE4 · N-Acetyl leukotriene E4 · leukotriene E4, N-acetyl- · 5S-HYDROXY-6R-(S-(N-ACETYL)CYSTEINYL)-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID · (5S,6R,7E,9E,11Z,14Z)-5-Hydroxy-6-[[(R)-2-acetylamino-2-carboxyethyl]thio]-7,9,11,14-icosatetraenoic acid · 7,9,11,14-Eicosatetraenoic acid, 6-[[(2R)-2-(acetylamino)-2-carboxyethyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)-
https://huagongshe.com/de/chemical/4341
Identifikatoren & physikalische Daten
| CAS No. | 80115-95-3 |
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| Summenformel | C25H39NO6S |
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| Durchschnittliche Molmasse | 481,6 g/mol |
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| Monoisotopische Masse | 481,24980914 g/mol |
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| SMILES | CCCCCC=CCC=CC=CC=CC(SCC(NC(C)=O)C(=O)O)C(O)CCCC(=O)O |
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| InChIKey | BGGYAYMMFYBWEX-UHFFFAOYSA-N |
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| PubChem CID | 4341 |
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| DTXSID | DTXSID801109007 |
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Chemische & physikalische Eigenschaften
| XLogP | 4,6 |
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| Polarare Oberfläche (TPSA) | 149 |
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| H-Brücken-Donoren | 4 |
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| H-Brücken-Akzeptoren | 7 |
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| Frei drehbare Bindungen | 19 |
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| Schwere Atome | 33 |
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| Formalladung | 0 |
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| Komplexität | 686 |
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| Lagerbedingungen | −20°C |
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| Löslichkeit | DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 0.1 mg/ml |
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| Aggregatzustand | Liquid. |
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Sicherheit & Vorschriften
| UN-Transportnummer | UN 1230 3/PG 2 |
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| R-Sätze (R) | 11 |
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| Gefahrensymbole | F,T |
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| Sicherheitshinweise (S) | 7-16-23-45 |
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Anwendungen & Verwendung
Verwenden
N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent. In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).
