Natriummethanthiolat

Sodium methanethiolate

HCID 4378561CAS 5188-07-8
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Grundinformationen

Standard-SMILES
C[S-].[Na+]
InChIKey
RMBAVIFYHOYIFM-UHFFFAOYSA-M
Summenformel
CH3NaS
Durchschnittliche Molmasse
70,09 g/mol
Monoisotopische Masse
69,98531555

Namen und Bezeichner

Bevorzugter Name
Sodium methanethiolate
IUPAC
sodium methanethiolate
Lokaler Name
Natriummethanthiolat
Englischer Name
Sodium thiomethoxide
Summenformel
CH3NaS
Molmasse
70.09

Namen und Synonyme

Sodium methanethiolate5188-07-8Sodium thiomethylateLB29JWW8H7RefChem:887680225-969-9Sodium thiomethoxideMethanethiol sodium saltMethyl mercaptan sodium saltsodium;methanethiolateCCRIS 9102Methanethiol, sodium salt (1:1)
Weitere Namen anzeigen
NaSMeSodium methylthiolatethioformateSODIUM METHYLMERCAPTANSodium methanethiolSODIUM THIOMETHOXIDE, 21 VOL. % SOLN IN WATER, A PRODUCT OF ELF ATOCHEM (SMM)
EINECS 225-969-9MFCD00174316UNII-LB29JWW8H7Sodium Methanethiolate (95%)Sodium Methanethiolate (95per cent)sodium methyl mercaptideEC 225-969-9sodiumthiomethoxide

Datenbank-Bezeichner

CAS
5188-07-8
PubChem CID
4378561
DTXSID
DTXSID7027592
UNII
LB29JWW8H7
EC Number
225-969-9
Nikkaji
J60.721E

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
1 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
0
Schwere Atome
3

Experimentelle und physikochemische Eigenschaften

Vapor Pressure0.00000108 [mmHg]
Physical DescriptionColorless liquid; [EPA ChAMP: Submission] Light brown solid; [Sigma-Aldrich MSDS] Strong offensive odor;

Physikochemische Eigenschaften

Dichte
1.12 · 1.12[at 20℃]
Dampfdruck
29 hPa · 29hPa at 25℃
Flammpunkt
27 °C · 27°C
storage temp.
Air and moisture sensitive. Store under inert gas. Sensitive to carbon dioxide Exposure to moisture.
Löslichkeit
soluble in Water
Aggregatzustand
Powder

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

Danger

H226 (18.8%): Flammable liquid and vapor [Warning Flammable liquids]；H228 (63.8%): Flammable solid [Danger Flammable solids]；H301 (79.7%): Toxic if swallowed [Danger Acute toxicity, oral]；H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H318 (20.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P270, P280, P301+P316, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 69 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Status: Active Update: 08-04-2011 https://echa.europa.eu/registration-dossier/-/registered-dossier/10183；Status: Active Update: 02-10-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/31705

Methanethiol, sodium salt: HSNO Approval: HSR007148 Approved with controls

Hazards Summary · 1 Eintrag

Changes of the blood, spleen (hematopoiesis and hemosiderosis), and liver (hematopoiesis) observed in oral study of rats at 45 mg/kg/day; No evidence of reproductive or developmental toxicity; [EPA - TSCATS] A severe skin irritant; Causes somnolence, dyspnea, and other gastrointestinal changes in oral lethal-dose studies of rats; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract; Toxic by ingestion; [Sigma-Aldrich MSDS] Reacts with water evolving methanethiol gas; [Alfa Aesar MSDS] See Methyl mercaptan.

Hazard Classes and CategoriesFlam. Liq. 3 (18.8%)；Flam. Sol. 2 (63.8%)；Acute Tox. 3 (79.7%)；Skin Corr. 1B (100%)；Eye Dam. 1 (20.3%)

Toxikologische Informationen

Adverse EffectsDermatotoxin - Skin burns.

Regulatorische Informationen

Regulatory Information · 2 Einträge

Status: Active Update: 08-04-2011 https://echa.europa.eu/registration-dossier/-/registered-dossier/10183；Status: Active Update: 02-10-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/31705

Methanethiol, sodium salt: HSNO Approval: HSR007148 Approved with controls

Sicherheitsdaten

F
1-34-10-13
wgk
3
tsca
TSCA listed
ridadr
UN 3263 8/PG 3
hs_code
29309090
risk_code
31-34-20/21/22-11-35-25-10

Chemie und Industrie

Verwendung und Herstellung

UsesUsed to make large scale and fine chemicals; [ECHA REACH Registrations]
General Manufacturing InformationMethanethiol, sodium salt (1:1): ACTIVE
Anwendungen · 2 Einträge

BeschreibungSodium methanethiolate or sodium thiomethoxide (CH3SNa, MeSNa) is the sodium conjugate base of methanethiol. This compound is commercially available as a white solid. Sodium Methanethiolate is used as a nucleophile in organic synthesis. This compound is also being used as a reagent to synthesize thiol-based suberoylanilide hydroxamic acid (SAHA) analogues, compounds that act as potent histone deacetylase inhibitors. It reacts with trifluoroacetic acid and water to produce the active form of sodium trifluoroacetate. The reaction mechanism is likely due to the formation of a bicyclic heterocycle that has been shown to be effective against a number of bacteria.

VerwendenSodium thiomethoxide is a strong nucleophile used for the synthesis of methyl aryl sulfides from halo-arenes. Alkanethiolates are efficient reagents for SN2 dealkylation of esters and aryl ethers.

Vor- und nachgelagerte Produkte

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国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
山东前元高分子材料有限公司18678041314 18765609661 · [email protected]
科瑞迪化学400-821-5857 021-64326257 · [email protected]

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