Kanamycinsulfat

Kanamycin A Sulfate

HCID 441374CAS 25389-94-0

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Grundinformationen

Standard-SMILES: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.O=S(=O)(O)O
InChIKey: OOYGSFOGFJDDHP-KMCOLRRFSA-N
Summenformel: C18H38N4O15S
Durchschnittliche Molmasse: 582,6 g/mol
Monoisotopische Masse: 582,20543769

Namen und Bezeichner

Bevorzugter Name: Kanamycin A Sulfate
IUPAC: (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
Lokaler Name: Kanamycinsulfat
Englischer Name: Kanamycin sulfate
Summenformel: C18H38N4O15S
Molmasse: 582.58

Namen und Synonyme

Kanamycin A sulfateKanamycin A sulphateDTXSID1047524J80EX28SMQEINECS 223-347-1(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acidCHEBI:6109DTXCID9027524KANAMYCIN A SULFATE [MI]KANAMYCIN SULFATE [USP-RS]KANAMYCIN SULFATE [USP MONOGRAPH]KANAMYCIN MONOSULFATE [EP MONOGRAPH]

Weitere Namen anzeigen

KANAMYCIN MONOSULFATEKANAMYCIN ACID SULFATEKANAMYCIN SULPHATEKantrexklebcilKanamycin AcidKanamycin monosulfate CRSkanoKAMYCINKantrim

KANAMYCIN SULFATE (USP-RS)KANAMYCIN SULFATE (USP MONOGRAPH)D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULFATE (1:1) (SALT)D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULPHATE (1:1) (SALT)D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl(1->4))-2-deoxy-, sulfate (1:1) (salt)KANAMYCIN MONOSULFATE (EP MONOGRAPH)Kanaplex(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-((1R,2R,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxyoxane-3,4,5-triol;sulfuric acid

Datenbank-Bezeichner

CAS: 25389-94-0、3847-27-6、64013-70-3
PubChem CID: 441374
DTXSID: DTXSID1047524
ChEMBL: CHEMBL1446
ChEBI: CHEBI:6109
UNII: J80EX28SMQ
EC Number: 223-347-1、613-414-7

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 366 Å²
H-Brücken-Donoren: 13
H-Brücken-Akzeptoren: 19
Frei drehbare Bindungen: 6
Schwere Atome: 38
Formalladung: 0
Komplexität: 720

Experimentelle und physikochemische Eigenschaften

Collision Cross Section221.1 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Physikochemische Eigenschaften

Schmelzpunkt: 250 °C · 250°C
Dichte: 1.3619 · 1.3619 (rough estimate)
Brechungsindex: 117.5 ° · 117.5 ° (C=1, H2O)
storage temp.: 2 · 2-8°C
Löslichkeit: 2 O: · H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
Aggregatzustand: powder
Farbe: white to off-white
Biologische Quelle: Streptomyces kanamyceticus
Wasserlöslichkeit: 10 mg/ml · Soluble in water at 10mg/ml
Merck: 14 · 14,5281
Major Application: pharmaceutical (small molecule)
InChIKey: OOYGSFOGFJDDHP-KMCOLRRFSA-N
SMILES: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 1% (1 of 96) of reports.

Danger

H360 (69.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]；H372 (29.2%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]；H400 (29.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (29.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 96 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 1 of 96 reports by companies.；There are 9 notifications provided by 95 of 96 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Hazard Classes and Categories · 2 Einträge

Repr. 1B (69.8%)；STOT RE 1 (29.2%)；Aquatic Acute 1 (29.2%)；Aquatic Chronic 1 (29.2%)

Repr. 1B (100%)

Sicherheitsdaten

wgk: 3
hs_code: 29419020
RTECS-Nr.: NZ3225030
risk_code: 61
Toxizität: LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)
hazard_code: T
safety_code: 22-24/25-45-53
Speicherklasse: 6.1D - Non-combustible acute toxic Cat.3toxic hazardous materials or hazardous materials causing chronic effects
Hazard Classifications: Repr. 1B

Chemie und Industrie

Verwendung und Herstellung

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Anwendungen · 2 Einträge

BeschreibungKanamycin was found by Umezawa et al. in the culture broth of Streptomyces kanamyceticus in 1957. It is produced with other components, kanamycins B (bekanamycin) and C, which are also separated during the purification. The compound shows much lower toxicity than the earlier aminoglycosides, streptomycin and neomycin, and strong activity against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium. Kanamycin has been used clinically for treatment of such serious infections as dysentery, salmonellosis, and tuberculosis.

VerwendenKanamycin sulfate is an antibacterial agent similar to neomycin.