Kanamycinsulfat
Kanamycin A Sulfate
Grundinformationen
- CAS
25389-94-0- Standard-SMILES
NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.O=S(=O)(O)O- InChIKey
OOYGSFOGFJDDHP-KMCOLRRFSA-N- Summenformel
- C18H38N4O15S
- Durchschnittliche Molmasse
- 582,6 g/mol
- Monoisotopische Masse
- 582,20543769
Überblick
Kanamycin A sulfate is an aminoglycoside sulfate salt. It has a role as a geroprotector and an antibacterial drug. It contains a kanamycin A.
Namen und Bezeichner
- Bevorzugter Name
- Kanamycin A Sulfate
- IUPAC
- (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
- Lokaler Name
- Kanamycinsulfat
- Englischer Name
- Kanamycin sulfate
- Summenformel
- C18H38N4O15S
- Molmasse
- 582.58
Namen und Synonyme
Kanamycin A sulfateKanamycin A sulphateKanaplexDTXSID1047524J80EX28SMQEINECS 223-347-1(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acidCHEBI:6109DTXCID9027524KANAMYCIN A SULFATE [MI]KANAMYCIN SULFATE (USP-RS)KANAMYCIN SULFATE [USP-RS]
Weitere Namen anzeigen
KANAMYCIN MONOSULFATEKANAMYCIN ACID SULFATEKANAMYCIN SULPHATEKantrexklebcilKanamycin AcidKanamycin monosulfate CRSkanoKAMYCINKantrim
KANAMYCIN SULFATE (USP MONOGRAPH)KANAMYCIN SULFATE [USP MONOGRAPH]KANAMYCIN MONOSULFATE (EP MONOGRAPH)KANAMYCIN MONOSULFATE [EP MONOGRAPH]D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULFATE (1:1) (SALT)D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULPHATE (1:1) (SALT)D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl(1->4))-2-deoxy-, sulfate (1:1) (salt)(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-((1R,2R,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxyoxane-3,4,5-triol;sulfuric acid
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 366 Ų
- H-Brücken-Donoren
- 13
- H-Brücken-Akzeptoren
- 19
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 38
- Formalladung
- 0
- Komplexität
- 720
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Collision Cross Section221.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 250 °C · 250°C
- Dichte
- 1.3619 · 1.3619 (rough estimate)
- Brechungsindex
- 117.5 ° · 117.5 ° (C=1, H2O)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 2 O: · H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Biologische Quelle
- Streptomyces kanamyceticus
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 1% (1 of 96) of reports.
Danger
H360 (69.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]
P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 96 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
Gefahrenhinweise
Hazard Classes and Categories
Repr. 1B (69.8%)
Repr. 1B (100%)
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29419020
- RTECS-Nr.
- NZ3225030
- risk_code
- 61
- Toxizität
- LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)
- hazard_code
- T
- safety_code
- 22-24/25-45-53
- Speicherklasse
- 6.1D - Non-combustible acute toxic Cat.3toxic hazardous materials or hazardous materials causing chronic effects
- Hazard Classifications
- Repr. 1B
Chemie und Industrie
Anwendungen
BeschreibungKanamycin was found by Umezawa et al. in the culture broth of Streptomyces kanamyceticus in 1957. It is produced with other components, kanamycins B (bekanamycin) and C, which are also separated during the purification. The compound shows much lower toxicity than the earlier aminoglycosides, streptomycin and neomycin, and strong activity against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium. Kanamycin has been used clinically for treatment of such serious infections as dysentery, salmonellosis, and tuberculosis.
VerwendenKanamycin sulfate is an antibacterial agent similar to neomycin.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Ergänzende Hinweise
DefinitionA broadspectrum antibiotic.
Zugehörige Reaktionen
11
Notizen zur Verbindung
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