Sievioside
Stevioside · GLUCOSYL STEVIOL GLYCOSIDES · STEVIA LEAF EXTRACT · Steviosides · Stevia 95% (froM Stevia rebaudiana) anhydrous · steviosin · Stevioside (90%) · Stevioside powder
Identifikatoren & physikalische Daten
| CAS No. | 57817-89-7 |
|---|---|
| Summenformel | C38H60O18 |
| Durchschnittliche Molmasse | 804,9 g/mol |
| Monoisotopische Masse | 804,37796506 g/mol |
| SMILES | C=C1C[C@@]23CC[C@H]4[C@@](C)(CCC[C@@]4(C)C(=O)O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H]2CC[C@]1(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C3 |
| InChIKey | UEDUENGHJMELGK-HYDKPPNVSA-N |
| PubChem CID | 442089 |
| ChEMBL | CHEMBL444122 |
| ChEBI | CHEBI:9271 |
| EC No. | 260-975-5 |
| DTXSID | DTXSID7021281 |
| Lokaler Name | Sievioside |
Chemische & physikalische Eigenschaften
| XLogP | -1,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 295 |
| H-Brücken-Donoren | 11 |
| H-Brücken-Akzeptoren | 18 |
| Frei drehbare Bindungen | 10 |
| Schwere Atome | 56 |
| Formalladung | 0 |
| Komplexität | 1.450 |
| Löslichkeit | 1.25 mg/mLDMSO: soluble25mg/mL, clear |
| Schmelzpunkt | 238 - 239 °C198°C |
| Physical Description | Solid |
| Collision Cross Section | 269.64 Ų [M+H]+ [CCS Type: TW] |
| Siedepunkt | 963.3±65.0 °C(Predicted) |
| Dichte | 1.53±0.1 g/cm3(Predicted) |
| Brechungsindex | -39.3 ° (C=6, H2O) |
| FEMA | 4728 | GLUCOSYL STEVIOL GLYCOSIDES |
| Lagerbedingungen | Sealed in dry,2-8°C |
| Aggregatzustand | powder |
| pKa (Säurekonstante) | 12.51±0.70(Predicted) |
| Farbe | white |
| Biologische Quelle | Stevia sp. |
| Merck | 14,8810 |
| Hauptanwendungen | cleaning productscosmeticsfood and beveragespersonal care |
| Kosmetik-Inhaltsstoffe Funktionen | ORAL CAREFRAGRANCE |
| InChIKey | ZBXJPXVJLBZBLI-IJGGXEOMSA-N |
| LogP (Verteilungskoeffizient) | 4.440 (est) |
| CAS Datenbank | 57817-89-7(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 85.7% (6 of 7) of all reports.WarningH315 (14.3%): Causes skin irritation [Warning Skin corrosion/irritation]H317 (14.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]H319 (14.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P261, P264, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 7 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 6 of 7 reports by companies.There is 1 notification provided by 1 of 7 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Chemical: Kaur-16-en-18-oic acid, 13-[(2-O-.beta.-D-glucopyranosyl-.beta.-D-glucopyranosyl)oxy]-, .beta.-D-glucopyranosyl ester, (4.alpha.)-Kaur-16-en-18-oic acid, 13-(2-O-.beta.-D-glucopyranosyl-.beta.-D-glucopyranosyl)oxy-, .beta.-D-glucopyranosyl ester, (4.alpha.)-: Does not have an individual approval but may be used under an appropriate group standard |
| Hazard Classes and Categories | Skin Irrit. 2 (14.3%)Skin Sens. 1 (14.3%)Eye Irrit. 2 (14.3%) |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 29389090 |
| RTECS-Nr. | NZ8175000 |
| Sicherheitshinweise (S) | 22-24/25 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Occurrence
Stevioside is a naturally occurring sweetener (～200 times sweeter than sucrose) extracted from a South American plant, Stevia rebaudiana Bertoni. The dried leaves, the water extract of leaves, and the refined chemical ingredients, eg, and Rebaudioside A (～300 times sweeter than sucrose), can all be used as sweetening agents. These are collectively referred to as stevia. Discovered in Paraguay and Brazil, the plant was identified in the early 1970s as a plant of high economical value and transported to Japan for cultivation, where the commercialization of stevia leaves extract as a natural sweetener became a success. Today Stevia plant is cultivated primarily in China.
History
Because no food additive petition has been presented to the FDA, stevioside and related materials cannot be used in the United States as food ingredients. An import alert against stevia was issued by the FDA in 1991. In 1995, however, the FDA revised this import alert to allow the importation and use of stevia as a dietary supplement, but not as a sweetener or an ingredient for foods. In 2004, JECFA (Joint Expert Committee of Food Additives) issued a preliminary ADI (Allowed Daily Intake) of 2-mg/kg body weight (based on steviol) for stevia extract. This action may impact favorably on worldwide regulatory approval. As consumer’s demand on naturally sweetened products increases, interest in Stevia, and naturally occurring potent sweeteners in general, is expected to grow. A comprehensive review of stevia is available [Kinghorn, 2002].