Vinpocetin

Vinpocetine

HCID 443955CAS 42971-09-5

Grundinformationen

Standard-SMILES
CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32
InChIKey
DDNCQMVWWZOMLN-IRLDBZIGSA-N
Summenformel
C22H26N2O2
Durchschnittliche Molmasse
350,5 g/mol
Monoisotopische Masse
350,19942807

Überblick

Vinpocetine is an alkaloid. It has a role as a geroprotector.

Namen und Bezeichner

Bevorzugter Name
Vinpocetine
IUPAC
ethyl (15S,19S)-15-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18),16-pentaene-17-carboxylate
Lokaler Name
Vinpocetin
Englischer Name
Vinpocetine
Summenformel
C22H26N2O2
Molmasse
350.46

Namen und Synonyme

vinpocetine42971-09-5CavintonCeractinBravintonVinporalApovincaminic acid ethyl esterEthyl apovincamin-22-oateUltra-VincaVinpocetinumRGH 4405cis-Apovincaminic acid ethyl ester
Weitere Namen anzeigen
VINPOCETINAppearanceEBURNAMENINEEthyl apovincaminate(3alpha,16alpha)-Eburnamenine-14-carboxylic acid ethyl esterTcv-3BCS-1570RGH-4405
Ethyl (+)-cis-apovincaminateTCV 3BVinpocetinaDTXSID5023740NSC-760093AY-27,255543512OBTCAY-27255

Datenbank-Bezeichner

CAS
42971-09-5
PubChem CID
443955
DTXSID
DTXSID5023740
ChEMBL
CHEMBL71752
ChEBI
CHEBI:32297
UNII
543512OBTC
EC Number
256-028-0
Nikkaji
J3.510F

Eigenschaften

Berechnete Struktureigenschaften

XLogP
4,1
Polarare Oberfläche (TPSA)
34,5 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
3
Frei drehbare Bindungen
4
Schwere Atome
26

Experimentelle und physikochemische Eigenschaften

DrugsPharmaceuticals -> Listed in ZINC15
LogP4.23
Solubility35.5 [ug/mL] (The mean of the results at pH 7.4)
Dietary IngredientsVinpocetine
Dissociation Constants7.1

Physikochemische Eigenschaften

Schmelzpunkt
147 · 147-153 °C dec.
Siedepunkt
484.44 °C · 484.44°C (rough estimate)
Dichte
1.126 · 1.1260 (rough estimate)
Brechungsindex
1.65 · 1.6500 (estimate)
storage temp.
2 · Sealed in dry,2-8°C
Löslichkeit
5 mg/mL · DMSO: 5 mg/mL

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 3 notifications to the ECHA C&L Inventory.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Sicherheitsdaten

wgk
3
hs_code
29399990
RTECS-Nr.
JW4792000
risk_code
22
Toxizität
LD50 in mice, rats (mg/kg): 534, 503 orally; 240, 133.8 i.p.; 58.7, 42.6 i.v. (Pálosi, Szporny), also reported as 161.2 mg/kg i.p. in mice (Cholnoky, Dmk)
hazard_code
Xn

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

N - Nervous system

QN - Nervous system

MeSH Pharmacological Classification · 4 Einträge

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

Drugs used to cause dilation of the blood vessels.

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms.

Anwendungen

VerwendenA calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) inhibitor

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

Zugehörige Reaktionen

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