5-Methyluridine (HCID 445408)

Überblick

Ribothymidine is a methyluridine having a single methyl substituent at the 5-position on the uracil ring. It has a role as an antigen, an Escherichia coli metabolite and a human metabolite.

Namen und Bezeichner

Bevorzugter Name: 5-Methyluridine
IUPAC: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Lokaler Name: 5-Methyluridin
Englischer Name: 5-Methyluridine
Summenformel: C10H14N2O6
Molmasse: 258.23

Namen und Synonyme

5-Methyluridine1463-10-1RibothymidineThymine ribosideRibosylthymineribosylthymidine1-(beta-D-ribofuranosyl)thymineCHEBI:45996ZS1409014ADTXSID201633481-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Weitere Namen anzeigen

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione5-Me-U5-Me-UrMethyluridine5-methyuridine5-methyl-uridinTHYMINERIBOSIDE

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methylpyrimidine-2,4-dioneRefChem:898086DTXCID9085839215-973-9Uridine, 5-methyl-5-Methyl UridineThymine ribofuranoside

Datenbank-Bezeichner

CAS: 1463-10-1
PubChem CID: 445408
DTXSID: DTXSID20163348
ChEMBL: CHEMBL106175
ChEBI: CHEBI:45996
UNII: ZS1409014A
EC Number: 215-973-9
Nikkaji: J32.354C

Eigenschaften

Berechnete Struktureigenschaften

XLogP: -1,6
Polarare Oberfläche (TPSA): 119 Å²
H-Brücken-Donoren: 4
H-Brücken-Akzeptoren: 6
Frei drehbare Bindungen: 2
Schwere Atome: 18
Formalladung: 0
Komplexität: 409

Experimentelle und physikochemische Eigenschaften

Melting Point183 - 187 °C

Physical DescriptionSolid

Collision Cross Section153.52 Å² [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]

Physikochemische Eigenschaften

Schmelzpunkt: 183 · 183-184 °C(lit.)
Dichte: 1.576 · 1.576±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit: Methanol (Slightly, Heated, Sonicated), Water (Sparingly, Sonicated)
pka: 9.55 · 9.55±0.10(Predicted)
Aggregatzustand: powder
Farbe: white
PH: 9.7 · 9.7
InChI: InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1
InChIKey: DWRXFEITVBNRMK-JXOAFFINSA-N
SMILES: OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](O)[C@@H]1O
CAS Datenbank: 1463 · 1463-10-1(CAS DataBase Reference)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 66.7% (2 of 3) of all reports.

Warning

H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory InformationStatus: Active Update: 09-02-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/31788

Hazard Classes and CategoriesSkin Irrit. 2 (33.3%)

Sicherheitsdaten

wgk: 3
hs_code: 29349990
risk_code: 26/27/28
hazard_code: T+
safety_code: 24/25
Speicherklasse: 11 - Combustible Solids

Chemie und Industrie

Pharmakologische Informationen

Tissue LocationsPlacenta

Cellular LocationsCytoplasm

Anwendungen · 2 Einträge

Beschreibung5-Methyluridine is a pyrimidine nucleoside and methylated form of uridine. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is an endogenous methylated nucleoside found in human fluids. In cells, 5-methyluridine is present in tRNA, formed during its post-transcriptional modification by the methylation of uridine.

VerwendenA primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.It enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model. It has been used to characterize the activity of a variety of enzymes, including uridine nucleosidase.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-5-methyl- (9CI)Uridine, 5-methyl-5'-O-(triphenylmethyl)-Uridine, 5-methyl-, 2',3',5'-triacetate Uridine, 5-methyl-, 2',3',5'-tribenzoate 2'-O-[2-[(diMethylaMino)oxy]ethyl]-5-Methyl-uridine 1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 1,2,3,5-TETRA-O-ACETYL-BETA-L-RIBOFURANOSE N3-Methyl-5-methyluridine BIS(O-TRIMETHYLSILYL)THYMINE Triethylammoniumfluorid 5-Methyluracil Guanosine

Nachgelagerte Produkte

1-β-D-Arabinofuranosyl-5-methyl-(1H,3H)-pyrimidin-2,4-dion Ethylbenzoat Stavudine

Anbieter50 Anbieter

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

INTATRADE GmbH+49 3493/605464 · [email protected]

河南福雷斯特新材料科技有限公司18639096640 · [email protected]

Zugehörige Reaktionen

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HRID 129097als Eduktuspto-grants-1995_11

HRID 381691als Eduktuspto-grants-2001_10

HRID 617427als Eduktuspto-grants-1999_09

HRID 722761als Eduktuspto-grants-2006_11

HRID 965182als Eduktuspto-grants-1998_06

HRID 1078177als Produktuspto-grants-1996_08

HRID 1379291als Eduktuspto-grants-1997_09

HRID 2072852als Eduktuspto-grants-1990_04

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Grundinformationen