Oxidopamin

6-Hydroxydopamine

HCID 4624CAS 1199-18-4

Grundinformationen

Standard-SMILES
NCCc1cc(O)c(O)cc1O
InChIKey
DIVDFFZHCJEHGG-UHFFFAOYSA-N
Summenformel
C8H11NO3
Durchschnittliche Molmasse
169,18 g/mol
Monoisotopische Masse
169,07389321

Überblick

6-hydroxydopamine is a solid. Used as a pharmacological agent.

Namen und Bezeichner

Bevorzugter Name
6-Hydroxydopamine
IUPAC
5-(2-aminoethyl)benzene-1,2,4-triol
Lokaler Name
Oxidopamin
Englischer Name
oxidopamine
Summenformel
C8H11NO3
Molmasse
169.18

Namen und Synonyme

oxidopamine6-HYDROXYDOPAMINE1199-18-45-(2-aminoethyl)benzene-1,2,4-triol2,4,5-TrihydroxyphenethylamineOxidopamina6-OHDAOxidopaminum5-(2-Aminoethyl)-1,2,4-benzenetriol1,2,4-Benzenetriol, 5-(2-aminoethyl)-8HW4YBZ748DTXSID0036768
Weitere Namen anzeigen
D016627Oxidopamine hydrobromideHydrobromide, oxidopamine
CHEBI:78741NSC2338986 HydroxydopamineRefChem:857156Hydrochloride, OxidopamineDTXCID8016768214-842-3Topamine

Datenbank-Bezeichner

CAS
1199-18-4
PubChem CID
4624
DTXSID
DTXSID0036768
ChEMBL
CHEMBL337702
ChEBI
CHEBI:78741
UNII
8HW4YBZ748
EC Number
214-842-3
Nikkaji
J126K

Eigenschaften

Berechnete Struktureigenschaften

XLogP
0,2
Polarare Oberfläche (TPSA)
86,7 Ų
H-Brücken-Donoren
4
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
2
Schwere Atome
12

Experimentelle und physikochemische Eigenschaften

Melting Point232 °C
Physical Description · 2 Einträge

6-hydroxydopamine is a solid. Used as a pharmacological agent.

Solid

Collision Cross Section · 2 Einträge

143 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]

143.2 Ų [M+H]+

Physikochemische Eigenschaften

Siedepunkt
298.46 °C · 298.46°C (rough estimate)
Dichte
1.2435 · 1.2435 (rough estimate)
Brechungsindex
1.51 · 1.5100 (estimate)
EPA chemische Informationen
6 · 6-Hydroxydopamine (1199-18-4)

Sicherheit und Regulatorisches

Gefahrenhinweise

DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to this chemical may include a prolonged decomposition in catecholamine content of the heart (shown to be due to the destruction of sympathetic nerve endings). (NTP, 1992)
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity Profile · 1 Eintrag

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Air and Water ReactionsNo rapid reaction with air. No rapid reaction with water.

Sicherheit und Schutzausrüstung

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 Eintrag

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill ResponseSTORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)
Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE) · 1 Eintrag

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 2 Einträge

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Tissue LocationsAdrenal Medulla
Cellular LocationsCytoplasm

Anwendungen

VerwendenAdrenergic (ophthalmic).

Anbieter5 Anbieter

陕西缔都新材料有限公司029-63373950 17392216152 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
BOC Sciences16314854226 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
Ergänzende Hinweise · 1 Eintrag

DefinitionChEBI: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Pa kinson's disease).

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