Hydrochloric Acid → 6-Hydroxydopamine hydrochloride

HRID 2280219

Reaktionsgleichung

Reaktionsgleichung von HRID 2280219
[CH:1]1[C:6]([OH:7])=[C:5]([OH:8])[CH:4]=[C:3]([OH:9])[C:2]=1[CH2:10][CH2:11][NH2:12].O=C1O[C@H]([C@H](CO)O)C(O)=C1O.CNCCCN1C2C=CC=CC=2CCC2C=CC=CC1=2.CN1[C@@H]2CC3C=CC(O)=C(O)C=3C3C2=C(C=CC=3)CC1.CCCN(CCC1C=CC=C2NC(=O)CC=12)CCC.[ClH:84]>O.CC(N(C)C)=O>[ClH:84].[OH:9][C:3]1[C:2]([CH2:10][CH2:11][NH2:12])=[CH:1][C:6]([OH:7])=[C:5]([OH:8])[CH:4]=1

Komponenten

9

Edukt 6

HCID 313Hydrochloric AcidHCID 2995DesipramineHCID 46246-HydroxydopamineHCID 5095RopiniroleHCID 6005ApomorphineHCID 54670067L-Ascorbic Acid

Produkt 1

HCID 1601576-Hydroxydopamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

6-OHDA was dissolved at 2 mg/mL in a physiolosical saline solution containing 0.2% L-ascorbic acid. Desipramine was dissolved at 10 mg/mL in a physiolosical saline solution in a hot-water bath. Apomorphine was dissolved at 0.1 mg/mL in a physiolosical saline solution. Ropinirole was dissolved in distilled water. Test compounds were dissolved in a solution containing 2% DMA, 100 or 200 mol % hydrochloric acid, and 98% of a 0.5% methyl cellulose solution.

Aufarbeitung

  1. dissolutionTest compounds were dissolved in a solution

Quellen und Nachweise

ORD-Eintrag
ord-49e0302577c14ed3acd10f41549187a3
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09138434B2

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