Phenylarsinoxid

Phenylarsine Oxide

HCID 4778CAS 637-03-6

Grundinformationen

Standard-SMILES
O=[As]c1ccccc1
InChIKey
BQVCCPGCDUSGOE-UHFFFAOYSA-N
Summenformel
C6H5AsO
Durchschnittliche Molmasse
168,02 g/mol
Monoisotopische Masse
167,95563628

Überblick

Phenylarsine oxide is an arsine oxide derived from phenylarsine. It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, an antineoplastic agent and an apoptosis inducer.

Namen und Bezeichner

Bevorzugter Name
Phenylarsine Oxide
IUPAC
arsorosobenzene
Lokaler Name
Phenylarsinoxid
Englischer Name
Phenylarsine oxide
Summenformel
C6H5AsO
Molmasse
168.02

Namen und Synonyme

phenylarsine oxide637-03-6OxophenylarsinearsorosobenzeneArzenePhenylarsenoxideArsenosobenzeneARSINE, OXOPHENYL-Phenyl arsine oxideFenylarsinoxidPhAsODTXSID5042249
Weitere Namen anzeigen
PolyalphaolefinsPAOPoly α-olefinsarsenoso-benzenoxophenyl-arsin
0HUR2WY345NSC-42470DTXCID3022249CHEBI:75253RefChem:861713211-275-32-(Hydroxypropyl)phenylarsinic acidBenzene, arsenoso-

Datenbank-Bezeichner

CAS
637-03-6
PubChem CID
4778
DTXSID
DTXSID5042249
ChEMBL
CHEMBL477683
ChEBI
CHEBI:75253
UNII
0HUR2WY345
EC Number
211-275-3
Nikkaji
J6.913B

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
17,1 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
0
Schwere Atome
8

Experimentelle und physikochemische Eigenschaften

Chemical ClassesMetals -> Arsenic Compounds, Organic
Physical DescriptionCrystals with a melting point of 144-146 degrees C; [Merck Index]

Physikochemische Eigenschaften

Schmelzpunkt
145 · 145-148 °C
storage temp.
Poison room
Löslichkeit
50 mg/mL · DMSO: 50 mg/mL
Aggregatzustand
powder
Farbe
white to yellow
Biologische Quelle
synthetic (organic)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Chemical: Arsine, oxophenyl-

Restricted substance: Phenylarsine oxide

Hazards Summary · 1 Eintrag

Acute or chronic arsenic poisoning may result from ingestion or inhalation of a sufficient dose; [MSDSonline] Not found in any pesticide products; [NPIRS] Almost nothing is known regarding health effects of organic arsenic compounds in humans. Studies in animals show that some simple organic arsenic compounds are less toxic than inorganic forms. Ingestion of methyl and dimethyl compounds can cause diarrhea and damage to the kidneys. [ATSDR ToxProfiles]

Hazard Classes and CategoriesAcute Tox. 3 (100%)

Sicherheit und Schutzausrüstung

Exposure Control and Personal Protection · 1 Eintrag

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

Permissible Exposure Limit (PEL)0.5 [mg/m3], as As

Sicherheitsdaten

wgk
3
tsca
TSCA listed
ridadr
UN 3465 6.1/PG 3
hs_code
29310099
RTECS-Nr.
CH8100000
risk_code
23/25-50/53

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 2 Einträge

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

Verwendung und Herstellung

UsesInhibits protein-tyrosine-phosphatase. [ChemIDplus] Used in veterinarian medicine as a poultry coccidiostat; [6949, Merck Index]
General Manufacturing InformationArsine, oxophenyl-: ACTIVE

Anwendungen

VerwendenPhenylarsine oxide is used as a poultry coccidiostat in veterinary medicine. It is also used in a membrane-permeable protein tyrosine phosphatase inhibitor.

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海仲因实业有限公司2537653158 16621191650 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: An arsine oxide derived from phenylarsine.

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