Proglumid

Proglumide

HCID 4922CAS 6620-60-6
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Grundinformationen

Standard-SMILES
CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1
InChIKey
DGMKFQYCZXERLX-UHFFFAOYSA-N
Summenformel
C18H26N2O4
Durchschnittliche Molmasse
334,4 g/mol
Monoisotopische Masse
334,18925731

Überblick

Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as an opioid analgesic, a cholinergic antagonist, a drug metabolite, an anti-ulcer drug, a gastrointestinal drug, a delta-opioid receptor agonist, a cholecystokinin antagonist and a xenobiotic metabolite. It contains a (R)-proglumide and a (S)-proglumide.

Namen und Bezeichner

Bevorzugter Name
Proglumide
IUPAC
4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
Lokaler Name
Proglumid
Englischer Name
Proglumide
Summenformel
C18H26N2O4
Molmasse
334.41

Namen und Synonyme

proglumide6620-60-64-benzamido-5-(dipropylamino)-5-oxopentanoic acidBinosideXylamidedl-proglumideMilidNulsaGastrotopicMidelidUlcutinProglumida
Weitere Namen anzeigen
ProMkxm242dlcr242w5219milide
XydeProglumidumPromidW-5219DTXSID7023516242 DLCR-242(+-)-4-Benzamido-N,N-dipropylglutaramic acid

Datenbank-Bezeichner

CAS
6620-60-6
PubChem CID
4922
DTXSID
DTXSID7023516
ChEMBL
CHEMBL316561
ChEBI
CHEBI:32058
UNII
EPL8W5565D
EC Number
229-567-4
Nikkaji
J3.421E

Eigenschaften

Berechnete Struktureigenschaften

XLogP
2,4
Polarare Oberfläche (TPSA)
86,7 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
10
Schwere Atome
24

Experimentelle und physikochemische Eigenschaften

Human DrugsPharmaceuticals
Collision Cross Section · 2 Einträge

181.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

186.48 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Physikochemische Eigenschaften

Schmelzpunkt
148 · 148-150°C
Siedepunkt
471.21 °C · 471.21°C (rough estimate)
Dichte
1.1944 · 1.1944 (rough estimate)
Brechungsindex
1.57 · 1.5700 (estimate)
storage temp.
Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit
DMSO (Slightly), Methanol (Slightly)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 3 Einträge

This chemical does not meet GHS hazard criteria for 100% (3 of 3) of all reports.

Not Classified

Aggregated GHS information provided per 3 reports by companies from 1 notifications to the ECHA C&L Inventory.

Gefahrenhinweise

Regulatory InformationREACH registered substance: Proglumide (EC: 229-567-4)
Other Safety InformationIMAP assessments - Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (.+-.)-: Human health tier I assessment
Hazard Classes and CategoriesNot Classified

Sicherheitsdaten

Toxizität
LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati)

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

A - Alimentary tract and metabolism

QA - Alimentary tract and metabolism

MeSH Pharmacological Classification · 1 Eintrag

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.

Verwendung und Herstellung

Use ClassificationPharmaceuticals
Anwendungen · 2 Einträge

BeschreibungProglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.

VerwendenAnticholinergic.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

Anbieter50 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
常州亚邦制药有限公司[email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
山东泰诚生物科技有限公司18769832557 18769832557 · [email protected]
武汉鹏垒生物科技有限公司15871464247 · [email protected]

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