Citric Acid → HCID 67566730, Verbindung

HRID 1191970

Reaktionsgleichung

Reaktionsgleichung von HRID 1191970
[Na:1].[CH3:2][CH2:3][CH2:4][N:5]([C:9]([CH:11]([NH:17][C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:19])[CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[O:10])[CH2:6][CH2:7][CH3:8].C(CN)O.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[Na:1].[CH3:2][CH2:3][CH2:4][N:5]([C:9]([CH:11]([NH:17][C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:19])[CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[O:10])[CH2:6][CH2:7][CH3:8]

Komponenten

6

Edukt 4

HCID 311Citric AcidHCID 700EthanolamineHCID 4922ProglumideHCID 5360545Sodium

Produkt 1

HCID 67566730HCID 67566730, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

In another embodiment, a composition for IV injection can be made as follows: add 4263 g of the sodium salt of proglumide to 15 L of water and 93 g of ethanolamine and stir until a clear solution is obtained. After buffering with citric acid, the solution is diluted to a volume of 30 L, then filtered under pressure in an inert gas into 40,000 glass vials which are sterilized under heat, yielding 40,000 vials each containing 106.6 mg sodium proglumide, equivalent to 100 mg proglumide.

Aufarbeitung

  1. customis obtained
  2. additionthe solution is diluted to a volume of 30 L
  3. filtrationfiltered under pressure in an inert gas into 40,000 glass vials which
  4. temperatureunder heat

Quellen und Nachweise

ORD-Eintrag
ord-ee737652bf5048daa246a908955b71cd
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08680145B1

Verknüpfte Notizen

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