Sevelamer carbonate
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Grundinformationen
- CAS
845273-93-0- Standard-SMILES
C=CC[NH3+].ClCC1CO1.O=C([O-])O- InChIKey
PADGNZFOVSZIKZ-UHFFFAOYSA-N- Summenformel
- C7H14ClNO4
- Durchschnittliche Molmasse
- 211,64 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Sevelamer carbonate
- Englischer Name
- Sevelamer carbonate
- Summenformel
- C7H14ClNO4
- Molmasse
- 211.64
Namen und Synonyme
SevelamSevelam carbonateSevelamer carbonateSEVELEMER CARBONATE2-Propen-1-aminepolymerwithSevelamer Carbonate, Technical GradeSIM862 Sevelamer Carbonate-----25gm2-Propen-1-amine polymer with (chloromethyl)oxirancarbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine2-Propen-1-amine polymer with (chloromethyl)oxirane carbonate
Datenbank-Bezeichner
- CAS
845273-93-0- PubChem CID
- 49800084
Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- Room Temperature, under inert atmosphere
- Löslichkeit
- 4.74 mg/mL · <4.74mg/mL in DMSO
- Aggregatzustand
- Solid
- Farbe
- White to Pale Beige
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)
- InChIKey
- PADGNZFOVSZIKZ-UHFFFAOYSA-N
- SMILES
- C(O)(O)=O.C(C1OC1)Cl.C(=C)CN
Sicherheit und Regulatorisches
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Sicherheitsdaten
- wgk
- WGK 3
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungSevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids.
VerwendenSevelamer Carbonate, a non-absorbed polymer is an oral phosphate binder in patients with kidney failure. It is reported that Sevelamer Carbonate is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients than calcium-based phosphate binders.
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