Nedocromil Sodium
Grundinformationen
- CAS
69049-74-7- Standard-SMILES
CCCc1c2oc(C(=O)[O-])cc(=O)c2cc2c(=O)cc(C(=O)[O-])n(CC)c12.[Na+].[Na+]- InChIKey
JQEKDNLKIVGXAU-UHFFFAOYSA-L- Summenformel
- C19H15NNa2O7
- Durchschnittliche Molmasse
- 415,3 g/mol
- Monoisotopische Masse
- 415,06439038
Namen und Bezeichner
- Bevorzugter Name
- Nedocromil Sodium
- IUPAC
- disodium;9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylate
- Englischer Name
- NEDOCROMIL SODIUM
- Summenformel
- C19H18NNaO7
- Molmasse
- 395.34
Namen und Synonyme
Weitere Namen anzeigen
Datenbank-Bezeichner
- CAS
69049-74-7- PubChem CID
- 50295
- DTXSID
DTXSID00219115- ChEMBL
CHEMBL915- ChEBI
CHEBI:7493- UNII
- ET8IF4KS1T
- EC Number
- 620-501-3
- Nikkaji
- J357.902F
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 127 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 29
- Formalladung
- 0
- Komplexität
- 742
Physikochemische Eigenschaften
- storage temp.
- 2 · Inert atmosphere,2-8°C
- Löslichkeit
- 2 O: · H2O: soluble20mg/mL, clear
- Aggregatzustand
- powder
- Farbe
- , white to beige to brown
- Wasserlöslichkeit
- 2 O: · H2O: 20mg/mL, clear
- InChI
- 1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2
- InChIKey
- JQEKDNLKIVGXAU-UHFFFAOYSA-L
- SMILES
- [Na+].[Na+].[n]1(c2c([c](cc1C(=O)[O-])=O)cc3c([o]c(c[c]3=O)C(=O)[O-])c2CCC)CC
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.
Warning
H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (83.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 6 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 1 of 6 reports by companies.;There are 2 notifications provided by 5 of 6 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Gefahrenhinweise
Other Safety Information
IMAP assessments - 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt: Human health tier I assessment;IMAP assessments - 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt: Environment tier I assessment
Sicherheitsdaten
- wgk
- 3
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances that reduce or suppress INFLAMMATION.
Compounds that prevent the release of inflammatory mediators from MAST CELLS.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Drugs that are used to treat asthma.
Anwendungen
BeschreibungNedocromil sodium is an antiallergic agent with broader mast cell stabilizing properties than related cromolyn sodium. Administered as an aerosol, it is useful in the treatment of bronchial asthma and related diseases.
VerwendenNedocromil Sodium (Technical Grade) is a medication considered as mast cell stabilizer which act to prevent wheezing, shortness of breath, and other breathing problems caused by asthma.
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