Calcium nitrate → Nedocromil Calcium

HRID 231806

Reaktionsgleichung

Reaktionsgleichung von HRID 231806
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]3[C:19](=[O:20])[CH:18]=[C:17]([C:21]([O-:23])=[O:22])[O:16][C:10]=3[C:11]=2[CH2:13][CH2:14][CH3:15])[C:6](=[O:24])[CH:5]=[C:4]1[C:25]([O-:27])=[O:26])[CH3:2].[Na+].[Na+].[N+]([O-])([O-])=O.[Ca+2:34].[N+]([O-])([O-])=O>O>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]3[C:19](=[O:20])[CH:18]=[C:17]([C:21]([O-:23])=[O:22])[O:16][C:10]=3[C:11]=2[CH2:13][CH2:14][CH3:15])[C:6](=[O:24])[CH:5]=[C:4]1[C:25]([O-:27])=[O:26])[CH3:2].[Ca+2:34]

Komponenten

4

Edukt 2

HCID 24963Calcium nitrateHCID 50295Nedocromil Sodium

Produkt 1

HCID 68731Nedocromil CalciumAusbeute 98,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A filtered solution of disodium 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano-[3,2-g]-quinoline-2,8-dicarboxylate (75 g) in water (500 ml) was treated with a filtered solution of calcium nitrate (77 g) in water (500 ml). The mixture was stirred (2 hours) and then filtered. The solid obtained was washed with water and acetone, slurried first with water and then reslurried with acetone (500 ml). The solid was filtered off and dried in vacuo at 65° C. to give the title compound (73 g, contains 19.3% w/w water).

Aufarbeitung

  1. filtrationfiltered
  2. customThe solid obtained
  3. washwas washed with water and acetone
  4. filtrationThe solid was filtered off
  5. customdried in vacuo at 65° C.

Quellen und Nachweise

ORD-Eintrag
ord-57b3f8b9794a4e8fba9c5aa374d32808
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04849427

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