Acetic Acid → 6-Hydroxy-1,2,3,4-tetrahydro-beta-carboline

HRID 6742

Reaktionsgleichung

Reaktionsgleichung von HRID 6742
[C:1](O)(=O)C.Cl.[NH2:6][CH2:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=2)[NH:11][CH:10]=1.C(=O)CC>CO>[CH2:1]1[C:10]2[NH:11][C:12]3[C:17](=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=3)[C:9]=2[CH2:8][CH2:7][NH:6]1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 527PropanalHCID 160436Serotonin Hydrochloride

Produkt 1

HCID 1599596-Hydroxy-1,2,3,4-tetrahydro-beta-carboline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

Acetic acid was added dropwise to a solution of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (200 mg) in 7 mL methanol until the pH=4. Propionaldehyde (0.2 mL) was added and the mixture was heated at 75° C. in a sealed tube for 1 h. The tube was cooled to rt and unsealed. The solvent was evaporated to yield 190 mg of 2,3,4,9-tetrahydro-1H-β-carbolin-6-ol.

Aufarbeitung

  1. temperatureThe tube was cooled to rt
  2. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-1f048dede2bf4d0c8393ab8fe5ff7f6b
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07084154B2

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