Xylometazolinhydrochlorid
Xylometazoline Hydrochloride
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Grundinformationen
- CAS
1218-35-5- Standard-SMILES
Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1.Cl- InChIKey
YGWFCQYETHJKNX-UHFFFAOYSA-N- Summenformel
- C16H24N2.ClH
- Durchschnittliche Molmasse
- 280,83 g/mol
- Monoisotopische Masse
- 280,17062648
Überblick
See also: Xylometazoline (has active moiety).
Namen und Bezeichner
- Bevorzugter Name
- Xylometazoline Hydrochloride
- IUPAC
- 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole;hydrochloride
- Lokaler Name
- Xylometazolinhydrochlorid
- Englischer Name
- Xylometazoline hydrochloride
- Summenformel
- C16H25ClN2
- Molmasse
- 280.84
Namen und Synonyme
Xylometazoline hydrochloride1218-35-5Xylometazoline HClNeo-Synephrine IIOtrivin hydrochlorideDTXSID3045223NSC-757378DTXCID1025223X5S84033NZXylometazoline hydrochloride (USP)2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline monohydrochloride1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, monohydrochloride
Weitere Namen anzeigen
XYLOMETAZOLIN HYDROCHLORIDEOlynthNovorinXyMelinTherapinBrizolinGalazolinNeo-Rinoleina
1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-, monohydrochlorideSinosilXylomet hclNazo-mistOtrivine hay fever forRefChem:58082Metarivin Soln. 0.1%Sinosil Nasal Decongestant
Datenbank-Bezeichner
- CAS
1218-35-5
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- Polarare Oberfläche (TPSA)
- 24,4 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 19
- Formalladung
- 0
- Komplexität
- 302
Experimentelle und physikochemische Eigenschaften
Human DrugsBreast Feeding; Lactation; Milk, Human; Adrenergic alpha-Agonists; Sympathomimetics; Nasal Decongestants
Collision Cross Section168.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 131 · 131-133 C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- Freely soluble in water, in ethanol (96 per cent) and in methanol.
- Aggregatzustand
- Solid
- Farbe
- Crystals
- Merck
- 14 · 14,10086
- Major Application
- forensics and toxicologyveterinary
- InChI
- InChI=1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
- InChIKey
- YGWFCQYETHJKNX-UHFFFAOYSA-N
- SMILES
- C(C1NCCN=1)C1C(=CC(C(C)(C)C)=CC=1C)C.Cl
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 74 reports by companies from 6 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory Information
Chemical: 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, monohydrochloride
Xylometazoline hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Toxikologische Informationen
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Sicherheitsdaten
- wgk
- 3
- tsca
- TSCA listed
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 29332900
- RTECS-Nr.
- NJ2390000
- risk_code
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
Verwendung und Herstellung
General Manufacturing Information1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, hydrochloride (1:1): ACTIVE
Anwendungen
VerwendenXylometazoline hydrochloride may be used as a reference standard in determining the xylometazoline hydrochloride content in samples of nasal drops using high performance liquid chromatography (HPLC).
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