Triprolidine hydrochloride monohydrate
Grundinformationen
- CAS
6138-79-0- Standard-SMILES
Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1.Cl.O- InChIKey
CUZMOIXUFHOLLN-UMVVUDSKSA-N- Summenformel
- C19H22N2.ClH.H2O
- Durchschnittliche Molmasse
- 332,9 g/mol
- Monoisotopische Masse
- 332,1655411
Überblick
Triprolidine hydrochloride monohydrate is an odorless white crystalline powder. Bitter taste. (NTP, 1992)
Namen und Bezeichner
- Bevorzugter Name
- Triprolidine hydrochloride monohydrate
- IUPAC
- 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrate;hydrochloride
- Englischer Name
- Triprolidine hydrochloride
- Summenformel
- C19H23ClN2
- Molmasse
- 332.87
Namen und Synonyme
TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE6138-79-0ActidilonVenenDTXSID0021410Pro-ActidilPro-EntraDTXCID201410CHEBI:32265Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, monohydrate, stereoisomerRefChem:1100506Triprolidine hydrochloride hydrate
Weitere Namen anzeigen
rate,stereoisomerTRIPROLIDINE HCL USPtrans-TriprolidineHClTripolidine HydrochlorideTriprolidine hydrochlorideTriprolidine HydrochloriseTRIPROLIDINEHYDROCHLORIDE,USPTriprolidine hydrochloride (347)triprolidinesigmareferencestandard
Triprolidine.HCl monohydrateTriprolidine HCl monohydratetrans-Triprolidine hydrochloride(E)-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine monohydrochloride monohydrate(E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine hydrochloride hydratePyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride, monohydrate, (E)-Triprolidine hydrochloride hydrate (JAN)Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)-
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 17,1 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 23
- Formalladung
- 0
- Komplexität
- 335
Experimentelle und physikochemische Eigenschaften
Solubilitygreater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Melting Point239 to 248 °F (NTP, 1992)
Physical DescriptionTriprolidine hydrochloride monohydrate is an odorless white crystalline powder. Bitter taste. (NTP, 1992)
Physikochemische Eigenschaften
- Schmelzpunkt
- 115 · 115-120°C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 1 in · alcohol: soluble1 in 1.5 of solvent
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Wasserlöslichkeit
- 10 g/100 · >=10 g/100 mL at 20 ºC
- Merck
- 13 · 13,9817
- Stabilität
- Stable, but discolours in light. Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 96 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationPyridine, 2-(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl-, monohydrochloride, monohydrate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)-: Environment tier I assessment
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards
SYMPTOMS: Symptoms of exposure to this compound may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea. (NTP, 1992)
Reactive GroupAmines, Phosphines, and Pyridines
Chemie und Industrie
Anwendungen
VerwendenTRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet
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