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Triprolidine hydrochloride monohydrate
TRIPROLIDINE HCL MONOHYDRATE · rate,stereoisomer · TRIPROLIDINE HCL USP · trans-TriprolidineHCl · Tripolidine Hydrochloride · Triprolidine hydrochloride · Triprolidine Hydrochlorise · TRIPROLIDINEHYDROCHLORIDE,USP
Identifikatoren & physikalische Daten
| CAS No. | 6138-79-0 |
|---|---|
| Summenformel | C19H22N2.ClH.H2O |
| Durchschnittliche Molmasse | 332,9 g/mol |
| Monoisotopische Masse | 332,1655411 g/mol |
| SMILES | Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1.Cl.O |
| InChIKey | CUZMOIXUFHOLLN-UMVVUDSKSA-N |
| PubChem CID | 5284472 |
| ChEMBL | CHEMBL3188034 |
| ChEBI | CHEBI:32265 |
| EC No. | 627-740-2 |
| DTXSID | DTXSID0021410 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 17,1 |
|---|---|
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 23 |
| Formalladung | 0 |
| Komplexität | 335 |
| Löslichkeit | greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)alcohol: soluble1 in 1.5 of solvent>=10 g/100 mL at 20 ºC |
| Schmelzpunkt | 239 to 248 °F (NTP, 1992)115-120°C |
| Physical Description | Triprolidine hydrochloride monohydrate is an odorless white crystalline powder. Bitter taste. (NTP, 1992) |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
| Merck | 13,9817 |
| Stabilität | Stable, but discolours in light. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H31H/b18-11+ |
| InChIKey | WYUYEJNGHIOFOC-NWBUNABESA-N |
| SMILES | C(=C/CN1CCCC1)(\C1=NC=CC=C1)/C1C=CC(C)=CC=1.Cl |
| LogP (Verteilungskoeffizient) | 4.223 (est) |
| CAS Datenbank | 6138-79-0(CAS DataBase Reference) |
| EPA chemische Informationen | Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)- (6138-79-0) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 96 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Pyridine, 2-(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl-, monohydrochloride, monohydrate: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)-: Environment tier I assessment |
| Brandgefahren | Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992) |
| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this compound may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea. (NTP, 1992) |
| Reaktive Gruppe | Amines, Phosphines, and Pyridines |
| Reactivity Profile | TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE discolors on exposure to light. It is an acidic salt and can neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions. |
| Air and Water Reactions | Water soluble. |
| Hazard Classes and Categories |
Anwendungen & Verwendung
Verwenden
TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet