[2R-[2α[2S*(3R*,4S*,5S*,7R*)3S*,5S*],5α,6β]]-6-[7-[5-Ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)tetrahydro-3-methyl-2-furyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-3-methylsalicylsure
Lasalocid
Daten werden ergänzt – lade die Seite später neu, um den aktuellen Stand zu sehen
Grundinformationen
- CAS
11054-70-9- Standard-SMILES
CC[C@@H](C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCc1ccc(C)c(O)c1C(=O)O)[C@H]1O[C@](CC)([C@H]2CC[C@](O)(CC)[C@H](C)O2)C[C@@H]1C- InChIKey
BBMULGJBVDDDNI-OWKLGTHSSA-N- Summenformel
- C34H54O8
- Durchschnittliche Molmasse
- 590,798 g/mol
- Monoisotopische Masse
- 590,38186869
Namen und Bezeichner
- Bevorzugter Name
- Lasalocid
- IUPAC
- (1S,9S)-1,5:6,9-Dianhydro-9-[(5S,6S,7R)-9-(2-carboxy-3-hydroxy-4-methylphenyl)-6-hydroxy-5,7-dimethyl-4-oxononan-3-yl]-3,4,7,8-tetradeoxy-6-ethyl-2-C-ethyl-1,8-dimethyl-D-xylo-nonitol
- Lokaler Name
- [2R-[2α[2S*(3R*,4S*,5S*,7R*)3S*,5S*],5α,6β]]-6-[7-[5-Ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)tetrahydro-3-methyl-2-furyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-3-methylsalicylsure
- Englischer Name
- Lasalocid
- Summenformel
- C34H54O8
- Molmasse
- 590.79
Namen und Synonyme
Lasalocid ALasalocidAids003766Aids-003766Ionophore X-537AAntibiotic X-537AX 537A, Lasalocid ALasalocid (Lasalocid-ANsc243046 (sodium salt)Lasalocid, 10 mM in DMSO
Datenbank-Bezeichner
- CAS
11054-70-9、25999-31-9- PubChem CID
- 5360807
- DTXSID
DTXSID9048485- ChEMBL
CHEMBL145347- ChEBI
CHEBI:92181- UNII
- W7V2ZZ2FWB
- EC Number
- 247-401-9
- Nikkaji
- J28.607I
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 110 · 110-114°; mp 100-109° (unsharp)
- Siedepunkt
- 735.7 · 735.7±60.0 °C(Predicted)
- Dichte
- 1.119 · 1.119±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C Freezer, Under inert atmosphere
- Löslichkeit
- Acetonitrile,(Slightly), Methanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- pka
- 3.15 · 3.15±0.39(Predicted)
- Farbe
- White to Off-White
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- Toxizität
- LD50 in mice (mg/kg): 40 i.p. (Berger); also reported as LD50 in mice (mg/kg): 146 orally, 64 i.p., J. W. Westley, "Antibiotics (Polyether)" in Kirk-Othmer Encyclopedia of Chemical Technology Vol. 3 (Interscience, New York, 3rd ed., 1978) p 61
Chemie und Industrie
Anwendungen
BeschreibungLasalocid is an ionophore antibiotic isolated from certain Streptomyces sp. and used in veterinary practice as a coccidiostat for gastrointestinal parasites. Lasalocid cytotoxicity targets cell metabolism, demonstrating EC50 values in the range of 7-20 μM in viability assays using chicken hepatoma LMH cells and rat myoblast L6 cells.
VerwendenLasalocid is a polyether ionophore with potent antibacterial activity isolated from Streptomyces lasaliensis, first reported in 1951. Lasalocid was developed as an animal health product for treatment of coccidia. Lasalocid is able to form neutral complexes with monovalent and divalent cations and transport the ions through apolar phase (including lipid bilayer membranes). Interestingly, lasalocid can also transport larger organic cations, e.g. protonated dopamine.
Anbieter41 Anbieter
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海赛可锐生物科技有限公司021-58000709 13120558703 · [email protected]
Aladdin Scientific[email protected]
孟成科技（上海）有限公司400-820-6829 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
Zugehörige Reaktionen
15
Notizen zur Verbindung
Wird geladen…